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New approaches for fabrication of microfluidic capillary electrophoresis devices with on-chip conductivity detection

Citation

Guijt, RM and Baltussen, E and van der Steen, G and Schasfoort, RBM and Schlautmann, S and Billiet, HAH and Frank, J and van Dedem, GWK and van den Berg, A, New approaches for fabrication of microfluidic capillary electrophoresis devices with on-chip conductivity detection, Electrophoresis, 22, (2) pp. 235-241. ISSN 0173-0835 (2001) [Refereed Article]


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The definitive published version is available online at: http://interscience.wiley.com

DOI: doi:10.1002/1522-2683(200101)22:2<235::AID-ELPS235>3.0.CO;2-O

Abstract

In practice, microfluidic systems are based on the principles of capillary electrophoresis (CE), for a large part due to the simplicity of electroosmotic pumping. In this contribution, a universal conductivity detector is presented that allows detection of charged species down to the M level. Additionally, powderblasting is presented as a novel technique for direct etching of microfluidic networks. This method allows creation of features down to 50 m with a total processing time (design to device) of less than one day. The performance of powderblasted devices with integrated conductivity detection is illustrated by the separation of lithium, sodium, and potassium ions and that of fumaric, malic, and citric acid.

Item Details

Item Type:Refereed Article
Keywords:Micro-total analysis systems Micromachining Capillary electrophoresis Conductivity detection
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Instrumental Methods (excl. Immunological and Bioassay Methods)
Objective Division:Manufacturing
Objective Group:Instrumentation
Objective Field:Scientific Instruments
Author:Guijt, RM (Dr Rosanne Guijt)
ID Code:32952
Year Published:2001
Web of Science® Times Cited:96
Deposited By:Chemistry
Deposited On:2007-11-02
Last Modified:2011-08-12
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