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On-Chip Contactless Four-Electrode Conductivity Detection for Capillary Electrophoresis Devices


Laugere, F and Guijt, RM and Bastemeijer, J and van der Steen, G and Berthold, A and Baltussen, E and Sarro, P and van Dedem, GWK and Vellekoop, M and Bossche, A, On-Chip Contactless Four-Electrode Conductivity Detection for Capillary Electrophoresis Devices, Analytical Chemistry, 75, (2) pp. 306-312. ISSN 0003-2700 (2003) [Refereed Article]

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2003 American Chemical Society

DOI: doi:10.1021/ac0157371


In this contribution, a capillary electrophoresis microdevice with an integrated on-chip contactless four-electrode conductivity detector is presented. A 6-cm-long, 70-m-wide, and 20-m-deep channel was etched in a glass substrate that was bonded to a second glass substrate in order to form a sealed channel. Four contactless electrodes (metal electrodes covered by 30-nm silicon carbide) were deposited and patterned on the second glass substrate for on-chip conductivity detection. Contactless conductivity detection was performed in either a two- or a four-electrode configuration. Experimental results confirmed the improved characteristics of the four-electrode configuration over the classical two-electrode detection setup. The four-electrode configuration allows for sensitive detection for varying carrier−electrolyte background conductivity without the need for adjustment of the measurement frequency. Reproducible electrophoretic separations of three inorganic cations (K+, Na+, Li+) and six organic acids are presented. Detection as low as 5 M for potassium was demonstrated.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Instrumental methods (excl. immunological and bioassay methods)
Objective Division:Manufacturing
Objective Group:Instrumentation
Objective Field:Scientific instruments
UTAS Author:Guijt, RM (Dr Rosanne Guijt)
ID Code:32947
Year Published:2003
Web of Science® Times Cited:85
Deposited By:Chemistry
Deposited On:2005-06-06
Last Modified:2011-08-12
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