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Chemical and Physical Processes for Integrated Temperature Control in Microfluidic Devices


Guijt, RM and Dodge, A and van Dedem, GWK and de Rooij, NF and Verpoorte, E, Chemical and Physical Processes for Integrated Temperature Control in Microfluidic Devices, Lab on a Chip, 3, (1) pp. 1-4. ISSN 1473-0197 (2003) [Refereed Article]

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The Royal Society of Chemistry 2003

DOI: doi:10.1039/b210629a


Microfluidic devices are a promising new tool for studying and optimizing (bio)chemical reactions and analyses. Many (bio)chemical reactions require accurate temperature control, such as for example thermocycling for PCR. Here, a new integrated temperature control system for microfluidic devices is presented, using chemical and physical processes to locally regulate temperature. In demonstration experiments, the evaporation of acetone was used as an endothermic process to cool a microchannel. Additionally, heating of a microchannel was achieved by dissolution of concentrated sulfuric acid in water as an exothermic process. Localization of the contact area of two flows in a microfluidic channel allows control of the position and the magnitude of the thermal effect.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Analytical chemistry not elsewhere classified
Objective Division:Manufacturing
Objective Group:Instrumentation
Objective Field:Instrumentation not elsewhere classified
UTAS Author:Guijt, RM (Dr Rosanne Guijt)
ID Code:32945
Year Published:2003
Web of Science® Times Cited:67
Deposited By:Chemistry
Deposited On:2005-06-06
Last Modified:2011-08-12

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