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Chemical and Physical Processes for Integrated Temperature Control in Microfluidic Devices
journal contribution
posted on 2023-05-16, 16:14 authored by Rosanne Guijt, Dodge, A, van Dedem, GWK, de Rooij, NF, Verpoorte, EMicrofluidic devices are a promising new tool for studying and optimizing (bio)chemical reactions and analyses. Many (bio)chemical reactions require accurate temperature control, such as for example thermocycling for PCR. Here, a new integrated temperature control system for microfluidic devices is presented, using chemical and physical processes to locally regulate temperature. In demonstration experiments, the evaporation of acetone was used as an endothermic process to cool a microchannel. Additionally, heating of a microchannel was achieved by dissolution of concentrated sulfuric acid in water as an exothermic process. Localization of the contact area of two flows in a microfluidic channel allows control of the position and the magnitude of the thermal effect.
History
Publication title
Lab on a ChipPagination
1-4ISSN
1473-0197Department/School
School of Natural SciencesPublisher
Royal Society of ChemistryPlace of publication
CambridgeRights statement
© The Royal Society of Chemistry 2003Repository Status
- Restricted