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Screening Tasmanian marine organisms for antiparasitic activity


Narkowicz, CK and Blackman, AJ and Lacey, E and Gill, J and Heiland, K, Screening Tasmanian marine organisms for antiparasitic activity, Phytochemistry Reviews, 3, (3) pp. 333-335. ISSN 1568-7767 (2004) [Refereed Article]

DOI: doi:10.1007/s11101-004-2882-6


Tasmania, the island state of Australia, lies between the latitudes 40°40′S and 43°40′S. For the current study, 455 marine macroorganisms were collected from Tasmania's eastern and south eastern coasts. Organic extracts of these organisms were tested for activity against an endoparasite (nematode) and three ectoparasites (fly, mite and flea); all parasites of significance for domestic animals. The less calcified "soft" bryozoans (n=23) were an exceptionally rich source of nematocidal extracts, with 35% having high nematocidal activity (LD99 < 250 μg/ml). Bryozoans have not previously been identified as sources of nematocidal or, more generally, anthelmintic compounds. The incidence of activity against each of the three test ectoparasites (fly, mite and flea) was similar, overall, with each parasite susceptible to approximately 12% of the extracts. Some 65% of extracts with ectoparasite activity were active against only one ectoparasite. A similar proportion (58%) of extracts with ectoparasite activity had insignificant nematocidal activity. Only six extracts were active against all three ectoparasites. These results indicate a low level of non-specific toxicity across the different parasite classes. © Springer 2005.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Medicinal and biomolecular chemistry
Research Field:Medicinal and biomolecular chemistry not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Narkowicz, CK (Dr Christian Narkowicz)
UTAS Author:Blackman, AJ (Dr Adrian Blackman)
ID Code:32934
Year Published:2004
Deposited By:Chemistry
Deposited On:2004-08-01
Last Modified:2005-07-07

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