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α-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the α-amyloid plaques in inducing neuronal injury

Citation

Dickson, TC and Chuckowree, JA and Chuah, MI and West, AK and Vickers, JC, α-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the α-amyloid plaques in inducing neuronal injury, Neurobiology of Disease, 18, (2) pp. 286-295. ISSN 0969-9961 (2005) [Refereed Article]

DOI: doi:10.1016/j.nbd.2004.10.001

Abstract

This study investigated the role of α-internexin in the neuronal alterations associated with β-amyloid plaque formation in Alzheimer's disease (AD). Cortical neurons could be defined by their variable content of neurofilament (NF) triplet and α-internexin proteins, with a distinct population of supragranular pyramidal cells containing α-internexin alone. Both NF triplet and α-internexin were localized to reactive axonal structures in physically damaged neurons in experimental trauma models. Similarly, NF triplet and α-internexin immunoreactive neurites were localized to plaques densely packed with β-amyloid fibrils in preclinical AD cases, indicating that certain plaques may cause structural injury or impediment of local axonal transport. However, α-internexin, and not NF triplet, ring-like reactive neurites were present in end-stage AD cases, indicating the relatively late involvement of neurons that selectively contain α-internexin. These results implicate the expression of specific intermediate filament proteins in a distinct hierarchy of differential neuronal vulnerability to AD. © 2004 Elsevier Inc. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Other Biological Sciences
Research Field:Biological Sciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Dickson, TC (Professor Tracey Dickson)
Author:Chuckowree, JA (Dr Jyoti Chuckowree)
Author:Chuah, MI (Dr Inn Chuah)
Author:West, AK (Professor Adrian West)
Author:Vickers, JC (Professor James Vickers)
ID Code:32820
Year Published:2005
Web of Science® Times Cited:32
Deposited By:Pathology
Deposited On:2005-08-01
Last Modified:2015-07-31
Downloads:0

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