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Treatment of Heroin Dependence


Ahmadi, J and Farrashbandi, H and Moosavinasab, M and Babaee, M and Firoozabadi, A and Mohagheghzadeh, M and Porter, J and Pridmore, S and Dehbozorgi, G, Treatment of Heroin Dependence, German Journal of Psychiatry, 7, (1) pp. 1-5. ISSN 1433-1055 (2004) [Refereed Article]


Objective: To test the efficacy of naltrexone, methadone and buprenorphine over a treatment period of 12 weeks. Methods: Subjects were randomized to receive naltrexone, methadone, or buprenorphine in a comparative study. Participants: Ninety-three (93) heroin-dependent males who met the DSM-IV criteria for heroin dependence and were seeking treatment. Subjects received methadone (31 patients), or buprenorphine (31 patients), or naltrexone (31 patients) in 2001 and 2002. Results: The mean dose of heroin use per day was 1.9 gm, and the mean duration of current heroin use was 2.8 years. Days retained in treatment were measured. Completion rates by group were 93.5% for the methadone group, 67.7% for the buprenorphine group, and 41.9% for the naltrexone group (p < 0.0001). Retention in the 60 mg methadone group was significantly better than in the 6 mg buprenorphine group (p = .01) and in the 50 mg naltrexone group (p < 0.0001). Buprenorphine group was significantly better than 50 mg naltrexone group (p=0.04). Conclusion: The results support the efficacy of methadone, buprenorphine, and naltrexone for the treatment of heroin dependence.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Mental health services
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Pridmore, S (Professor Saxby Pridmore)
ID Code:32730
Year Published:2004
Deposited By:Psychiatry
Deposited On:2004-08-01
Last Modified:2005-05-31

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