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Effects of antioxidant supplementation on blood cyclosporine A and glomerular filtration rate in renal transplant recipients

Citation

Blackhall, ML and Fassett, RG and Sharman, JE and Geraghty, DP and Coombes, JS, Effects of antioxidant supplementation on blood cyclosporine A and glomerular filtration rate in renal transplant recipients, Nephrology, Dialysis and Transplantation, 20, (9) pp. 1970-1975. ISSN 0931-0509 (2005) [Refereed Article]


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The definitive publisher-authenticated version is available online at: http://www.oxfordjournals.org/

Official URL: http://www.oxfordjournals.org/

DOI: doi:10.1093/ndt/gfh875

Abstract

Background. Transplant recipients have elevated oxidative stress, which has prompted suggestions that supplementary antioxidants may be beneficial. However, only a small number of clinical trials have investigated antioxidant supplementation in transplant recipients, with very few data on their effects on patients' immunosuppressive therapy. Methods. A randomized placebo-controlled single-blind crossover trial was conducted in 10 renal transplant recipients (RTRs) taking cyclosporin A (CsA) as part of their immunosuppressive therapy. Each phase of the trial lasted 6 months, with a 6 month wash-out period in between. During one of the phases, patients consumed a tablet twice per day which delivered 400 IU/day of vitamin E, 500 mg/day of vitamin C and 6 mg/day of -carotene. Results. During antioxidant supplementation, there was no change in CsA dose. Antioxidant supplementation resulted in a significant decrease (P<0.05) in blood trough CsA by 24% (meanSD, pre- 127.338.9, post- 97.230.7 g/ml) compared with no change while taking the placebo (pre- 132.250.6, post- 138.656.0 g/ml). The glomerular filtration rate was significantly (P<0.05) improved by 12% during antioxidant supplementation (pre- 66.920.7, post- 75.020.1ml/min/ 1.72 m2), with no change during the placebo phase (pre- 66.811.8, post- 66.716.1 ml/min/1.72 m2). There were no significant differences (P>0.05) in markers of oxidative stress (malondialdehyde, susceptibility of plasma to oxidation) or plasma antioxidant enzymes. Conclusion. In CsA-treated RTRs, antioxidant supplementation decreased blood CsA, which may affect adequacy of immunosuppression.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Nephrology and Urology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Urogenital System and Disorders
Author:Blackhall, ML (Mrs Melanie Blackhall)
Author:Fassett, RG (Professor Robert Fassett)
Author:Sharman, JE (Professor James Sharman)
Author:Geraghty, DP (Professor Dominic Geraghty)
Author:Coombes, JS (Associate Professor Jeff Coombes)
ID Code:32720
Year Published:2005
Web of Science® Times Cited:20
Deposited By:Health Sciences A
Deposited On:2005-08-01
Last Modified:2012-11-28
Downloads:0

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