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Intrinsic Regenerative Ability of Mature CNS Neurons
journal contribution
posted on 2023-05-16, 16:01 authored by Jyoti ChuckowreeJyoti Chuckowree, Tracey DicksonTracey Dickson, James VickersJames VickersA prevailing view in neuroscience is that the mature CNS has relatively little capacity to respond adaptively to injury. Recent data indicating a high degree of structural plasticity in the adult brain provides an impetus to reexamine how central neurons react to trauma. An analysis of both in vivo and in vitro experimental studies demonstrates that certain brain neurons may have an intrinsic ability to respond to structural injury by an attempt at regenerative sprouting. Indeed, aberrant sprouting following neuronal injury may be the cause of epilepsy following brain trauma and may underlie the neuronal changes stimulated by plaque formation in Alzheimer's disease. An understanding of the stereotypical reaction to injury of different CNS neurons, as well as the role of nonneuronal cells, may provide new avenues for therapeutic intervention for a range of neurodegenerative diseases and "acquired" forms of CNS injury.
History
Publication title
NeuroscientistVolume
10Issue
4Pagination
280-285ISSN
1073-8584Department/School
Tasmanian School of MedicinePublisher
Sage PublicationsPlace of publication
California, USARepository Status
- Restricted