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Intrinsic Regenerative Ability of Mature CNS Neurons


Chuckowree, JA and Dickson, TC and Vickers, JC, Intrinsic Regenerative Ability of Mature CNS Neurons, Neuroscientist, 10, (4) pp. 280-285. ISSN 1073-8584 (2004) [Refereed Article]

DOI: doi:10.1177/1073858404263511


A prevailing view in neuroscience is that the mature CNS has relatively little capacity to respond adaptively to injury. Recent data indicating a high degree of structural plasticity in the adult brain provides an impetus to reexamine how central neurons react to trauma. An analysis of both in vivo and in vitro experimental studies demonstrates that certain brain neurons may have an intrinsic ability to respond to structural injury by an attempt at regenerative sprouting. Indeed, aberrant sprouting following neuronal injury may be the cause of epilepsy following brain trauma and may underlie the neuronal changes stimulated by plaque formation in Alzheimer's disease. An understanding of the stereotypical reaction to injury of different CNS neurons, as well as the role of nonneuronal cells, may provide new avenues for therapeutic intervention for a range of neurodegenerative diseases and "acquired" forms of CNS injury.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Other biological sciences
Research Field:Other biological sciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Chuckowree, JA (Dr Jyoti Chuckowree)
UTAS Author:Dickson, TC (Professor Tracey Dickson)
UTAS Author:Vickers, JC (Professor James Vickers)
ID Code:32372
Year Published:2004
Web of Science® Times Cited:28
Deposited By:Pathology
Deposited On:2004-08-01
Last Modified:2015-08-05

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