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A role for extracellular metallothioneins in CNS injury and repair


Chung, RS and West, AK, A role for extracellular metallothioneins in CNS injury and repair, Neuroscience, 123, (3) pp. 595-599. ISSN 0306-4522 (2004) [Letter or Note in Journal]

DOI: doi:10.1016/j.neuroscience.2003.10.019


For many years, research focus on metallothioneins, small zinc binding proteins found predominantly within astrocytes in the brain, has centred on their ability to indirectly protect neurons from oxygen free radicals and heavy metal-induced neurotoxicity. However, in recent years it has been demonstrated that these proteins have previously unsuspected roles within the cellular response to brain injury. The aim of this commentary is to provide an overview of the exciting recent experimental evidence from several laboratories including our own suggesting a possible extracellular role for these proteins, and to present a hypothetical model explaining the newly identified function of extracellular metallothioneins in CNS injury and repair. © 2003 IBRO. Published by Elsevier Ltd. All rights reserved.

Item Details

Item Type:Letter or Note in Journal
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Chung, RS (Associate Professor Roger Chung)
UTAS Author:West, AK (Professor Adrian West)
ID Code:32069
Year Published:2004
Web of Science® Times Cited:80
Deposited By:Anatomy and Physiology
Deposited On:2004-08-01
Last Modified:2011-09-14

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