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Molecular Modelling and Design of Radiolabelled Complexes for Melanoma Diagnosis

journal contribution
posted on 2023-05-16, 15:38 authored by Tuttle, CTT, Seabrook, SA, Wise, LE, Katsifis, A, Knott, RB, Brian YatesBrian Yates
Molecular modelling has been used to analyze a database of compounds with known binding affinities for the integrin receptors αVβ3 and αIIbβ3. We describe how a variety of novel radiolabelled compounds (specifically 131I labelled) were designed and how the binding affinity of these compounds to the two integrin receptors was predicted. The selectivity for the αVβ3 receptor has also been predicted and a summary of some of the best candidates for positron emission tomography (PET) imaging is provided. This work will have significant implications for the development of diagnostic (and possibly therapeutic) drugs for melanomas.

History

Publication title

Australian Journal of Chemistry

Volume

57

Pagination

87-96

ISSN

0004-9425

Department/School

School of Natural Sciences

Publisher

CSIRO Publishing

Place of publication

Collingwood

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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