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Molecular Modelling and Design of Radiolabelled Complexes for Melanoma Diagnosis

Citation

Tuttle, CTT and Seabrook, SA and Wise, LE and Katsifis, A and Knott, RB and Yates, BF, Molecular Modelling and Design of Radiolabelled Complexes for Melanoma Diagnosis, Australian Journal of Chemistry, 57, (1) pp. 87-96. ISSN 0004-9425 (2004) [Refereed Article]

DOI: doi:10.1071/CH03165

Abstract

Molecular modelling has been used to analyze a database of compounds with known binding affinities for the integrin receptors αVβ3 and αIIbβ3. We describe how a variety of novel radiolabelled compounds (specifically 131I labelled) were designed and how the binding affinity of these compounds to the two integrin receptors was predicted. The selectivity for the αVβ3 receptor has also been predicted and a summary of some of the best candidates for positron emission tomography (PET) imaging is provided. This work will have significant implications for the development of diagnostic (and possibly therapeutic) drugs for melanomas.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Medicinal and Biomolecular Chemistry
Research Field:Medicinal and Biomolecular Chemistry not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Tuttle, CTT (Mr Christopher Tuttle)
Author:Seabrook, SA (Mr Shane Anthony Seabrook)
Author:Wise, LE (Miss Lauren Wise)
Author:Yates, BF (Professor Brian Yates)
ID Code:31985
Year Published:2004
Web of Science® Times Cited:2
Deposited By:Chemistry
Deposited On:2004-08-01
Last Modified:2005-05-30
Downloads:0

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