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Molecular Modelling and Design of Radiolabelled Complexes for Melanoma Diagnosis
journal contribution
posted on 2023-05-16, 15:38 authored by Tuttle, CTT, Seabrook, SA, Wise, LE, Katsifis, A, Knott, RB, Brian YatesBrian YatesMolecular modelling has been used to analyze a database of compounds with known binding affinities for the integrin receptors αVβ3 and αIIbβ3. We describe how a variety of novel radiolabelled compounds (specifically 131I labelled) were designed and how the binding affinity of these compounds to the two integrin receptors was predicted. The selectivity for the αVβ3 receptor has also been predicted and a summary of some of the best candidates for positron emission tomography (PET) imaging is provided. This work will have significant implications for the development of diagnostic (and possibly therapeutic) drugs for melanomas.
History
Publication title
Australian Journal of ChemistryVolume
57Pagination
87-96ISSN
0004-9425Department/School
School of Natural SciencesPublisher
CSIRO PublishingPlace of publication
CollingwoodRepository Status
- Restricted