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Dopaminergic neurons protected from degeneration by GDNF gene therapy


Choi-Lundberg, DL and Lin, Q and Chang, YN and Chiang, YL and Hay, CM and Mohajeri, H and Davidson, BL and Bohn, MC, Dopaminergic neurons protected from degeneration by GDNF gene therapy, Science, 275, (5301) pp. 838-841. ISSN 0036-8075 (1997) [Refereed Article]

DOI: doi:10.1126/science.275.5301.838


Glial cell line-derived neurotrophic factor (GDNF) supports growth and survival of dopaminergic (DA) neurons. A replication-defective adenoviral (Ad) vector encoding human GDNF injected near the rat substantia nigra was found to protect DA neurons from the progressive degeneration induced by the neurotoxin 6- hydroxydopamine (6-OHDA) injected into the striatum. Ad GDNF gene therapy reduced loss of DA neurons approximately threefold 6 weeks after 6-OHDA lesion, as compared with no treatment or injection of Ad lacZ or Ad mGDNF (encoding a biologically inactive deletion mutant GDNF). These results suggest that Ad vector-mediated GDNF gene therapy may slow the DA neuronal cell loss in humans with Parkinson's disease.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Choi-Lundberg, DL (Dr Derek Choi-Lundberg)
ID Code:31632
Year Published:1997
Web of Science® Times Cited:530
Deposited By:Anatomy and Physiology
Deposited On:2005-03-08
Last Modified:2011-08-15

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