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Dopaminergic neurons protected from degeneration by GDNF gene therapy
Citation
Choi-Lundberg, DL and Lin, Q and Chang, YN and Chiang, YL and Hay, CM and Mohajeri, H and Davidson, BL and Bohn, MC, Dopaminergic neurons protected from degeneration by GDNF gene therapy, Science, 275, (5301) pp. 838-841. ISSN 0036-8075 (1997) [Refereed Article]
DOI: doi:10.1126/science.275.5301.838
Abstract
Glial cell line-derived neurotrophic factor (GDNF) supports growth and survival of dopaminergic (DA) neurons. A replication-defective adenoviral (Ad) vector encoding human GDNF injected near the rat substantia nigra was found to protect DA neurons from the progressive degeneration induced by the neurotoxin 6- hydroxydopamine (6-OHDA) injected into the striatum. Ad GDNF gene therapy reduced loss of DA neurons approximately threefold 6 weeks after 6-OHDA lesion, as compared with no treatment or injection of Ad lacZ or Ad mGDNF (encoding a biologically inactive deletion mutant GDNF). These results suggest that Ad vector-mediated GDNF gene therapy may slow the DA neuronal cell loss in humans with Parkinson's disease.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Central Nervous System |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Nervous System and Disorders |
| Author: | Choi-Lundberg, DL (Dr Derek Choi-Lundberg) |
| ID Code: | 31632 |
| Year Published: | 1997 |
| Web of Science® Times Cited: | 491 |
| Deposited By: | Anatomy and Physiology |
| Deposited On: | 2005-03-08 |
| Last Modified: | 2011-08-15 |
| Downloads: | 0 |
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