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The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake

Citation

Clerk, LC and Vincent, MA and Lindner, J and Clark, MG and Rattigan, S and Barrett, EJ, The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake, Diabetes/Metabolism Reseach and Reviews, 20, (1) pp. 3-12. ISSN 1520-7552 (2004) [Refereed Article]

DOI: doi:10.1002/dmrr.414

Abstract

Whether a discrete vascular action of insulin in skeletal muscle integrally participates in insulin-mediated glucose disposal has been extensively examined but remains a contentious issue. Here, we review some of the data both supporting and questioning the role of insulin-mediated increases in limb blood flow in glucose metabolism. We advance the hypothesis that controversy has arisen, at least in part, from a failure to recognize that insulin exerts at least three separate actions on the peripheral vasculature, each with its own characteristic dose and time responsiveness. We summarize how, viewed in this manner, certain points of contention can be resolved. We also advance the hypothesis that an action on the precapillary arteriole may play the dominant role in mediating perfusion-dependent effects of insulin on glucose metabolism in muscle. Copyright © 2003 John Wiley & Sons, Ltd.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Vincent, MA (Dr Michelle Keske)
Author:Clark, MG (Professor Michael Clark)
Author:Rattigan, S (Professor Stephen Rattigan)
ID Code:31437
Year Published:2004
Web of Science® Times Cited:68
Deposited By:Biochemistry
Deposited On:2004-08-01
Last Modified:2010-03-24
Downloads:0

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