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The scaffold protein, Homer 1b/c, regulates axon pathfinding in the central nervous system in vivo

Citation

Foa, LC and Rajan, I and Haas, K and Wu, G and Brakeman, P and Worley, P and Cline, H, The scaffold protein, Homer 1b/c, regulates axon pathfinding in the central nervous system in vivo, Nature Neuroscience, 4, (5) pp. 499-506. ISSN 1097-6256 (2001) [Refereed Article]

DOI: doi:10.1038/87447

Abstract

Homer proteins are a family of multidomain cytosolic proteins that have been postulated to serve as scaffold proteins that affect responses to extracellular signals by regulating protein-protein interactions. We tested whether Homer proteins are involved in axon pathfinding in vivo, by expressing both wild-type and mutant isoforms of Homer in Xenopus optic tectal neurons. Time-lapse imaging demonstrated that interfering with the ability of endogenous Homer to form protein-protein interactions resulted in axon pathfinding errors at stereotypical choice points. These data demonstrate a function for scaffold proteins such as Homer in axon guidance. Homer may facilitate signal transduction from cell-surface receptors to intracellular proteins that govern the establishment of axon trajectories.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Foa, LC (Professor Lisa Foa)
ID Code:31363
Year Published:2001
Web of Science® Times Cited:52
Deposited By:Anatomy and Physiology
Deposited On:2005-03-08
Last Modified:2005-03-08
Downloads:0

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