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Reduced Bone Density Among Children With Severe Hemophilia


Barnes, C and Wong, P and Egan, B and Speller, T and Cameron, F and Jones, G and Ekert, H and Monagle, P, Reduced Bone Density Among Children With Severe Hemophilia, Pediatrics, 114, (2) pp. 177-181. ISSN 0031-4005 (2004) [Refereed Article]

DOI: doi:10.1542/peds.114.2.e177


OBJECTIVE: Children with severe hemophilia are at risk for reduced bone mineral density (BMD) because of reduced weight-bearing exercise and hepatitis C infection. Reduced bone density in childhood is a risk factor for osteoporosis in later life. STUDY DESIGN: We performed a cross-sectional survey of bone density among 19 children with severe hemophilia, at the Royal Children's Hospital. Results were correlated with findings of blinded objective evaluations of the joints of the lower limb and with hepatitis C status. RESULTS: The mean lumbar bone mineral apparent density for patients was reduced (0.102 g/cm3), compared with that for control subjects (0.113 g/cm3). The mean areal BMD z score was -0.92, which was significantly reduced, compared with that for control subjects. The difference in bone density was independent of body size. There was a statistically significant relationship between the lumbar BMD z scores and the maximal single joint evaluation scores, but there was no difference based on hepatitis C status. CONCLUSIONS: Our results suggest that children with severe hemophilia have reduced BMD. Patients at risk are those with signs of hemophilic arthropathy. Because osteoporosis may complicate the future treatment of patients with hemophilia, screening of young patients for reduced bone density is recommended.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Paediatrics
Research Field:Paediatrics not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:31266
Year Published:2004
Web of Science® Times Cited:99
Deposited By:Menzies Centre
Deposited On:2004-08-01
Last Modified:2005-05-09

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