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Accuracy, reproducibility and clinical utility of the CoaguChek S portable international normalized ratio monitor in an outpatient anticoagulation clinic

Citation

Jackson, SL and Bereznicki, LRE and Peterson, GM and Marsden, KA and Jupe, DML and Tegg, EM and Vial, JH and Kimber, R, Accuracy, reproducibility and clinical utility of the CoaguChek S portable international normalized ratio monitor in an outpatient anticoagulation clinic, Clinical and Laboratory Haematology, 26, (1) pp. 49-55. ISSN 0141-9854 (2004) [Refereed Article]


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Copyright Statement

The definitive published version is available online at: http://onlinelibrary.wiley.com/

Official URL: http://onlinelibrary.wiley.com/

DOI: doi:10.1111/j.0141-9854.2003.00578.x

Abstract

The accuracy and reproducibility of the CoaguChek S, and its clinical agreement with conventional laboratory international normalized ratio (INR) determination, were evaluated in an outpatient anticoagulation clinic setting. Forty-three patients provided 248 paired INR measurements for analysis. The paired results were highly correlated (r = 0.90). The mean coefficient of variation for the CoaguChek S for a random sample of 21 patients with three repeated tests each, was 4%. Clinical applicability was also measured by discrepant INR values, as defined in the literature by expanded and narrow agreement, and by INR values resulting in a different clinical decision by a blinded haematology registrar. Expanded agreement and narrow agreement between the two INR values occurred 90 and 88% of the time, respectively. The stricter criteria set down by the clinician resulted in 73% of paired results producing the same dosage decision. The CoaguChek S displayed good correlation with laboratory determination of INR and compared relatively well with expanded and narrow clinical agreement criteria.

Item Details

Item Type:Refereed Article
Keywords:Warfarin;international normalized ratio;point-of-care;monitor;clinical agreement
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Health and Community Services
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Jackson, SL (Dr Shane Jackson)
Author:Bereznicki, LRE (Associate Professor Luke Bereznicki)
Author:Peterson, GM (Professor Gregory Peterson)
Author:Marsden, KA (Dr Katherine Marsden)
Author:Tegg, EM (Dr Elizabeth Tegg)
Author:Vial, JH (Associate Professor Janet Vial)
Author:Kimber, R (Dr Roger Kimber)
ID Code:30004
Year Published:2004
Web of Science® Times Cited:17
Deposited By:Pharmacy
Deposited On:2004-08-01
Last Modified:2012-03-14
Downloads:0

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