No relationship between low density lipoproteins and endothelial function in hemodialysis patients
Dalton, BS and Fassett, RG and Geraghty, DP and De Ryke, R and Coombes, JS, No relationship between low density lipoproteins and endothelial function in hemodialysis patients, International Journal of Cardiology, 99, (2) pp. 307-314. ISSN 0167-5273 (2005) [Refereed Article]
Background: Relationships between low-density lipoprotein cholesterol and endothelial function in hemodialysis patients have yet to be investigated. Furthermore, current reporting of endothelial function data using flow-mediated dilatation has recognised limitations. The aims of the study were to determine the relationship between low-density lipoproteins and endothelial function in hemodialysis patients and to investigate the validity of determining the area under the curve for data collected during the flow-mediated dilatation technique. Methods: Brachial artery responses to reactive hyperemia (endothelial-dependent) and glyceryl trinitrate (endothelial-independent) were assessed in 19 hemodialysis patients using high-resolution ultrasound. Lipid profiles and other factors known to effect brachial artery reactivity were also measured prior to the flow-mediated dilatation technique. Results: There were no significant relationships between serum low-density lipoproteins and endothelial-dependent or -independent vasodilation using absolute change (mm), relative change (%), time to peak change (s) or area under the curve (mm·s). In hemodialysis patients with atherosclerosis, area under the curve analysis showed a significantly (p<0.05) decreased endothelial-dependent response (meanąS.D.: 19.2ą17.4) compared to non-atherosclerotic patients (42.3ą28.6). However, when analysing these data using absolute change, relative change or time to peak dilatation, there were no significant differences between the two groups. Conclusions: In summary, there was no relationship between low-density lipoproteins and endothelial function in hemodialysis patients. In addition, area under the curve analysis of flow-mediated vasodilatation data may be a useful method of determining the temporal vascular response during the procedure.
Area under the curve; Atherosclerosis; Endothelial dysfunction; Flow-mediated dilatation; Low-density lipoproteins; Reactive hyperemia