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Measuring environmental factors can enhance the search for disease causing genes?


Dwyer, T and Ponsonby, AL and Stankovich, J and Blizzard, CL and Easteal, S, Measuring environmental factors can enhance the search for disease causing genes?, Journal of Epidemiology and Community Health, 58, (7) pp. 613-615. ISSN 0143-005X (2004) [Refereed Article]

DOI: doi:10.1136/jech.2003.012971


The value of the concurrent measurement of environmental factors in studies aimed at the discovery of disease causing genes has been questioned on the grounds that such an approach fails to increase study power. This report discusses the issue and shows with examples from the recent literature that the examination of a gene disease association within an environmental subgroup can provide enhanced opportunities for detecting gene effects. The concurrent collection of environmental as well as genetic factors in studies of disease aetiology may enhance study informativeness and validity in several ways, including an increase in the power of the study to detect gene disease associations.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Ponsonby, AL (Professor Anne Ponsonby)
UTAS Author:Stankovich, J (Dr Jim Stankovich)
UTAS Author:Blizzard, CL (Professor Leigh Blizzard)
ID Code:29638
Year Published:2004
Web of Science® Times Cited:8
Deposited By:Menzies Centre
Deposited On:2004-08-01
Last Modified:2005-06-22

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