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Measuring environmental factors can enhance the search for disease causing genes?

Citation

Dwyer, T and Ponsonby, AL and Stankovich, J and Blizzard, CL and Easteal, S, Measuring environmental factors can enhance the search for disease causing genes?, Journal of Epidemiology and Community Health, 58, (7) pp. 613-615. ISSN 0143-005X (2004) [Refereed Article]

DOI: doi:10.1136/jech.2003.012971

Abstract

The value of the concurrent measurement of environmental factors in studies aimed at the discovery of disease causing genes has been questioned on the grounds that such an approach fails to increase study power. This report discusses the issue and shows with examples from the recent literature that the examination of a gene disease association within an environmental subgroup can provide enhanced opportunities for detecting gene effects. The concurrent collection of environmental as well as genetic factors in studies of disease aetiology may enhance study informativeness and validity in several ways, including an increase in the power of the study to detect gene disease associations.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Environmental Health
Author:Dwyer, T (Professor Terry Dwyer)
Author:Ponsonby, AL (Professor Anne Ponsonby)
Author:Stankovich, J (Dr Jim Stankovich)
Author:Blizzard, CL (Associate Professor Leigh Blizzard)
ID Code:29638
Year Published:2004
Web of Science® Times Cited:7
Deposited By:Menzies Centre
Deposited On:2004-08-01
Last Modified:2005-06-22
Downloads:0

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