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Progressive dementia after first-ever stroke - A community-based follow-up study
Citation
Srikanth, V and Anderson, JFI and Donnan, GA and Saling, MM and Didus, E and Alpitsis, R and Dewey, HM and Macdonell, RAL and Thrift, AG, Progressive dementia after first-ever stroke - A community-based follow-up study, Neurology, 63, (5) pp. 785-792. ISSN 0028-3878 (2004) [Refereed Article]
DOI: doi:10.1212/01.WNL.0000137042.01774.33
Abstract
Objectives: To examine the risk and determinants of a progressive dementia syndrome and cognitive impairment not dementia (CIND) in community-based nonaphasic first-ever stroke cases 1 year after stroke, relative to a matched community-based stroke-free group. Methods: Matched cohort design, with cognitive tests given on two occasions 9 months apart to 99 mild-to-moderate first-ever stroke patients and 99 age- and sex-matched people without stroke. At follow-up, progressive dementia or CIND were diagnosed, with judges blinded to stroke/nonstroke status. Results: Progressive dementia was diagnosed in 12.5% of stroke patients and 15.4% of those without strokes (RR 1.1, 95% CI 0.5 to 2.2, p = 0.85). CIND was diagnosed in 37.5% of stroke patients and 17.6% of participants without strokes (RR 2.1, 95% CI 1.2 to 3.4, p = 0.003). In multivariable regression, age (p = 0.04) and baseline cognition (p < 0.001) were independently associated with dementia whereas stroke (p = 0.002), age (p = 0.05), baseline cognition (p = 0.001), and baseline mood (p = 0.03) were independently associated with CIND at follow-up. Conclusions: In this community-based nonaphasic sample, mild-to moderate first-ever stroke was not associated with the presence of progressive dementia 1 year later, but was clearly associated with a greater risk of cognitive impairment not dementia (CIND). Baseline mood impairment remained independently associated with CIND at 1 year after taking into account stroke, age, and baseline cognitive ability.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Geriatrics and gerontology |
Objective Division: | Health |
Objective Group: | Other health |
Objective Field: | Other health not elsewhere classified |
UTAS Author: | Srikanth, V (Dr Velandai Srikanth) |
ID Code: | 29592 |
Year Published: | 2004 |
Web of Science® Times Cited: | 54 |
Deposited By: | Menzies Centre |
Deposited On: | 2004-08-01 |
Last Modified: | 2011-11-23 |
Downloads: | 0 |
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