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Increased risk of cognitive impairment 3 months after mild to moderate first-ever stroke. A community-based prospective study of non-aphasic English-speaking survivors
Citation
Srikanth, V and Thrift, AG and Saling, MM and Anderson, JFI and Dewey, HM and Macdonell, RA and Donnan, GA, Increased risk of cognitive impairment 3 months after mild to moderate first-ever stroke. A community-based prospective study of non-aphasic English-speaking survivors, Stroke, 34, (5) pp. 1136-1143. ISSN 0039-2499 (2003) [Refereed Article]
DOI: doi:10.1161/01.STR.0000069161.35736.39
Abstract
Background and Purpose - Results of hospital-based studies indicate a high risk of cognitive impairment 3 months after stroke. There are no comprehensive data on this issue from prospective community-based studies comparing first-ever stroke patients with stroke-free subjects. Methods - We administered a comprehensive neuropsychological battery to 99 community-based nonaphasic survivors of first-ever stroke at 3 months and 99 age- and sex-matched (1:1) stroke-free individuals. Domain-specific cognitive deficits were identified by blinded neuropsychological consensus. Methods - Stroke patients were more likely to suffer any cognitive impairment (relative risk [RR], 1.5; 95% CI, 1.1 to 2.1) attributable mainly to a greater risk of single-domain cognitive impairment (RR, 2.8; 95% CI, 1.5 to 5.3) but not multiple-domain cognitive impairment (RR, 1.2; 95% CI, 0.8 to 1.9). Conclusions - In this community-based study, a first-ever stroke of mild to moderate severity was associated with a significant risk of cognitive impairment at 3 months, even in the absence of clinical aphasia. This was due primarily to an increased risk of solitary deficits rather than generalized deficits.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Geriatrics and gerontology |
Objective Division: | Health |
Objective Group: | Other health |
Objective Field: | Other health not elsewhere classified |
UTAS Author: | Srikanth, V (Dr Velandai Srikanth) |
ID Code: | 29583 |
Year Published: | 2003 |
Web of Science® Times Cited: | 90 |
Deposited By: | Menzies Centre |
Deposited On: | 2004-08-04 |
Last Modified: | 2004-08-04 |
Downloads: | 0 |
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