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Endurance training in wistar rats decreases receptor sensitivity to a serotonin agonist


Dwyer, DB and Browning, J, Endurance training in wistar rats decreases receptor sensitivity to a serotonin agonist, Acta Physiologica Scandinavica, 170, (3) pp. 211-216. ISSN 0001-6772 (2000) [Refereed Article]

DOI: doi:10.1046/j.1365-201x.2000.00774.x


There is mounting evidence that increased brain serotonin during exercise is associated with the onset of CNS-mediated fatigue. Serotonin receptor sensitivity is likely to be an important determinant of this fatigue. Alterations in brain serotonin receptor sensitivity were examined in Wistar rats throughout 6 weeks of endurance training, running on a treadmill four times a week with two exercise tests per week to exhaustion. Receptor sensitivity was determined indirectly as the reduction in exercise time in response to a dose of a serotonin (1A) agonist, m-chlorophenylpiperazine (m-CPP). The two groups of controls were used to examine (i) the effect of the injection per se on exercise performance and (ii) changes in serotonin receptor sensitivity associated with maturation. In the test group, undrugged exercise performance significantly improved by 47% after 6 weeks of training (4518 ± 729 to 6640 ± 903 s, P= 0.01). Drugged exercise performance also increased significantly from week 1 to week 6 (306 ± 69-712 ± 192 s, P = 0.04). Control group results indicated that the dose of m-CPP alone caused fatigue during exercise tests and that maturation was not responsible for any decrease in receptor sensitivity. Improved resistance to the fatiguing effects of the serotonin agonist suggests desensitization of central serotonin receptors, probably the 5-HT1A receptors. Endurance training appears to stimulate an adaptive response to the fatiguing effects of increased brain serotonin, which may enhance endurance exercise performance.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Dwyer, DB (Dr Dan Dwyer)
ID Code:29521
Year Published:2000
Web of Science® Times Cited:19
Deposited By:Health Sciences A
Deposited On:2004-10-19
Last Modified:2004-10-19

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