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Antibody response to sheep red blood cells in platypus and echidna


Wronski, E and Woods, GM and Munday, BL, Antibody response to sheep red blood cells in platypus and echidna, Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology, 136, (4) pp. 957-963. ISSN 1095-6433 (2003) [Refereed Article]

DOI: doi:10.1016/S1095-6433(03)00325-8


There is limited information regarding the kinetics of antibody responses exhibited by the platypus and the echidna in response to a T cell dependent antigen. In this preliminary study a platypus, an echidna and a rabbit were inoculated with sheep red blood cells to compare their antibody responses and kinetics. The antibody titres, produced by the platypus and echidna, were less than those elicited in the rabbit. Furthermore, the echidna and platypus exhibited a weak secondary response. This was most likely due to a failure of the platypus and echidna to undergo the characteristic IgM to IgG isotype switch following second antigen exposure. The conformational structure of these antibodies may differ from eutherian antibodies. This was further supported by a heat sensitivity experiment that indicated that these antibodies are more labile than rabbit immunoglobulins and therefore structurally less stable. © 2003 Elsevier Inc. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Veterinary sciences
Research Field:Veterinary immunology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the environmental sciences
UTAS Author:Wronski, E (Dr Eileen Wronski)
UTAS Author:Woods, GM (Professor Gregory Woods)
UTAS Author:Munday, BL (Dr Barry Munday)
ID Code:29197
Year Published:2003
Web of Science® Times Cited:9
Deposited By:Health Sciences A
Deposited On:2003-08-01
Last Modified:2011-09-30

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