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Prolongation of heart allograft survival of rats treated by a Th2 inhibitor


Hsu, LW and Goto, S and Lin, YC and Lai, CY and Tseng, HP and Wu, Cl and Lord, RJ and Kitano, S and Chen, SH and Chen, CL, Prolongation of heart allograft survival of rats treated by a Th2 inhibitor, Transplant Immunology, 11, (3-4) pp. 385-388. ISSN 0966-3274 (2003) [Letter or Note in Journal]

DOI: doi:10.1016/S0966-3274(02)00152-1


In terms of Th1/Th2 balance in response to signals given during donor antigen presentation, induction of tolerance is more often correlated with Th2-type than with Th1-type reactions. However, in our study, heart allograft survival was prolonged by treatment of rats with a Th2 inhibitor. Suplatast tosilate (IPD; Taiho; Tokyo, Japan) is a novel immunoregulator that suppresses IgE production and eosinophil infiltration through selective inhibition of interleukin (IL)-4 and IL-5 synthesis by Th2-like cells but not IFN-γ production in Th1 cells. Five LEW rats of DA heart grafts were treated with IPD (100 μg/day, p.o.) for 10 days. Heart allograft survival of all IPD-treated cases was prolonged more than 14 days while the beating of heart grafts in control groups was stopped within 9 days. In an in vitro study, the cell proliferation both in Con A blast and in mixed lymphocyte reaction assay was suppressed by IPD in dose-dependent manner. We could at least in part conclude that Th2 inhibition might temporarily suppress heart allograft rejection. © 2002 Elsevier Science B.V. All rights reserved.

Item Details

Item Type:Letter or Note in Journal
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Transplantation immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Lord, RJ (Dr Roger Lord)
ID Code:29083
Year Published:2003
Web of Science® Times Cited:5
Deposited By:Surgery
Deposited On:2003-08-01
Last Modified:2004-07-07

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