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Prolongation of heart allograft survival of rats treated by a Th2 inhibitor
Citation
Hsu, LW and Goto, S and Lin, YC and Lai, CY and Tseng, HP and Wu, Cl and Lord, RJ and Kitano, S and Chen, SH and Chen, CL, Prolongation of heart allograft survival of rats treated by a Th2 inhibitor, Transplant Immunology, 11, (3-4) pp. 385-388. ISSN 0966-3274 (2003) [Letter or Note in Journal]
DOI: doi:10.1016/S0966-3274(02)00152-1
Abstract
In terms of Th1/Th2 balance in response to signals given during donor antigen presentation, induction of tolerance is more often correlated with Th2-type than with Th1-type reactions. However, in our study, heart allograft survival was prolonged by treatment of rats with a Th2 inhibitor. Suplatast tosilate (IPD; Taiho; Tokyo, Japan) is a novel immunoregulator that suppresses IgE production and eosinophil infiltration through selective inhibition of interleukin (IL)-4 and IL-5 synthesis by Th2-like cells but not IFN-γ production in Th1 cells. Five LEW rats of DA heart grafts were treated with IPD (100 μg/day, p.o.) for 10 days. Heart allograft survival of all IPD-treated cases was prolonged more than 14 days while the beating of heart grafts in control groups was stopped within 9 days. In an in vitro study, the cell proliferation both in Con A blast and in mixed lymphocyte reaction assay was suppressed by IPD in dose-dependent manner. We could at least in part conclude that Th2 inhibition might temporarily suppress heart allograft rejection. © 2002 Elsevier Science B.V. All rights reserved.
Item Details
Item Type: | Letter or Note in Journal |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Immunology |
Research Field: | Transplantation immunology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Lord, RJ (Dr Roger Lord) |
ID Code: | 29083 |
Year Published: | 2003 |
Web of Science® Times Cited: | 5 |
Deposited By: | Surgery |
Deposited On: | 2003-08-01 |
Last Modified: | 2004-07-07 |
Downloads: | 0 |
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