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Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease
journal contribution
posted on 2023-05-16, 14:42 authored by James VickersJames Vickers, Tan, A, Tracey DicksonTracey DicksonWe investigated the cellular localisation of neurofibrillary tangles in Alzheimer's disease. All tau-positive tangles were stained for thioflavine S, while ∼84% of thioflavine S-stained tangles were tau-immunolabelled. Approximately 58-62% and 73-76% of thioflavine S- and tau-labelled tangles, respectively, were present within cortical neurons labelled for microtubule-associated protein-2. Thus, most neocortical tangles in Alzheimer's disease are intracellular and may not be the principal cause of neocortical cell loss. © 2003 Elsevier Science B.V. All rights reserved.
History
Publication title
Brain ResearchVolume
971Pagination
135-137ISSN
0006-8993Department/School
Tasmanian School of MedicinePublisher
Elsvier Science BVPlace of publication
USARepository Status
- Restricted