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Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease

Citation

Vickers, JC and Tan, A and Dickson, TC, Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease, Brain Research, 971, (1) pp. 135-137. ISSN 0006-8993 (2003) [Refereed Article]

DOI: doi:10.1016/S0006-8993(03)02429-6

Abstract

We investigated the cellular localisation of neurofibrillary tangles in Alzheimer's disease. All tau-positive tangles were stained for thioflavine S, while ∼84% of thioflavine S-stained tangles were tau-immunolabelled. Approximately 58-62% and 73-76% of thioflavine S- and tau-labelled tangles, respectively, were present within cortical neurons labelled for microtubule-associated protein-2. Thus, most neocortical tangles in Alzheimer's disease are intracellular and may not be the principal cause of neocortical cell loss. © 2003 Elsevier Science B.V. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Vickers, JC (Professor James Vickers)
Author:Tan, A (Miss Adeline Tan)
Author:Dickson, TC (Associate Professor Tracey Dickson)
ID Code:28431
Year Published:2003
Web of Science® Times Cited:6
Deposited By:Pathology
Deposited On:2003-08-01
Last Modified:2004-04-21
Downloads:0

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