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Hereditary diffuse leucoencephalopathy with spheroids


Hancock, N and Poon, M and Taylor, BV and McLean, C, Hereditary diffuse leucoencephalopathy with spheroids, Journal of Neurology, Neurosurgery and Psychiatry, 74, (9) pp. 1345-1347. ISSN 0022-3050 (2003) [Refereed Article]

DOI: doi:10.1136/jnnp.74.9.1345


Hereditary diffuse leucoencephalopathy with spheroids (HDLS) is a rare inherited progressive leucoencephalopathy characterised by giant neuroaxonal swellings (spheroids) within the CNS white matter. The case is reported of a 45 year old woman with a rapidly progressive fulminant illness course characterised by progressive cognitive decline with depressive features. A presumed dominant inheritance pattern was elicited. This report reviews the literature on HDLS and the relation of this disorder to other conditions with giant neuroaxonal swellings.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Taylor, BV (Professor Bruce Taylor)
ID Code:27780
Year Published:2003
Web of Science® Times Cited:33
Deposited By:Medicine
Deposited On:2003-08-01
Last Modified:2004-03-22

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