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Hereditary diffuse leucoencephalopathy with spheroids
journal contribution
posted on 2023-05-16, 14:31 authored by Hancock, N, Poon, M, Bruce TaylorBruce Taylor, McLean, CHereditary diffuse leucoencephalopathy with spheroids (HDLS) is a rare inherited progressive leucoencephalopathy characterised by giant neuroaxonal swellings (spheroids) within the CNS white matter. The case is reported of a 45 year old woman with a rapidly progressive fulminant illness course characterised by progressive cognitive decline with depressive features. A presumed dominant inheritance pattern was elicited. This report reviews the literature on HDLS and the relation of this disorder to other conditions with giant neuroaxonal swellings.
History
Publication title
Journal of Neurology, Neurosurgery and PsychiatryVolume
74Issue
9Pagination
1345-1347ISSN
0022-3050Department/School
Tasmanian School of MedicinePublisher
BMJ Publishing GroupPlace of publication
United KingdomRepository Status
- Restricted