eCite Digital Repository

A randomized controlled trial of phytoestrogen supplementation, growth and bone turnover in adolescent males


Jones, G and Dwyer, T and Hynes, K and Dalais, FS and Parameswaran, V and Greenaway, TM, A randomized controlled trial of phytoestrogen supplementation, growth and bone turnover in adolescent males, European Journal of Clinical Nutrition, 57, (2) pp. 324-327. ISSN 0954-3007 (2003) [Refereed Article]

DOI: doi:10.1038/sj.ejcn.1601544


Objective: To assess the effect of phytoestrogens on bone turnover and growth in adolescent boys. Design: Randomized double-blind placebo-controlled trial. Setting: Single school in northwest Tasmania. Participants: Adolescent boys (treatment n = 69, placebo n = 59, mean age 16.8 y). Interventions: Six weeks of isoflavone supplementation (Novasoy, 50 mg daily of isoflavone equivalents). Bone turnover markers (bone specific alkaline phosphatase (BAP) and pyridinoline creatinine ratio (PYR)) were measured at baseline and follow-up. Results: Despite marked increases in urinary genistein and daidzein in the treatment arm (both P < 0.001), there were no significant differences in BAP, PYR or short-term height or weight change. This applied to both intention-to-treat and per protocol analysis. Neither was there a significant correlation between urinary genistein and daidzein levels and BAP or PYR. Conclusions: Phytoestrogen supplementation to the level of usual Japanese dietary intake has no measurable effect on bone turnover in adolescent boys. Longer-term studies of bone density may be desirable but it is unlikely that there will be a large effect in either girls or boys given the lower endogenous oestrogen levels in boys.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Health services and systems not elsewhere classified
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Hynes, K (Dr Kristen Hynes)
UTAS Author:Parameswaran, V (Associate Professor Venkat Parameswaran)
UTAS Author:Greenaway, TM (Dr Tim Greenaway)
ID Code:27704
Year Published:2003
Web of Science® Times Cited:15
Deposited By:Medicine
Deposited On:2003-08-01
Last Modified:2004-03-22

Repository Staff Only: item control page