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Ion-exclusion chromatography with conductimetric detection of aliphatic carboxylic acids on a weakly acidic cation-exchange resin by elution with benzoic acid-beta-cyclodextrin

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posted on 2023-05-16, 14:22 authored by Tanaka, K, Mori, M, Xu, Q, Halaleh, MIH, Ikedo, M, Taoda, H, Hu, W, Hasebe, K, Fritz, J, Paul HaddadPaul Haddad
In this study, an aqueous solution consisting of benzoic acid with low background conductivity and β-cyclodextrin (β-CD) of hydrophilic nature and the inclusion effect to benzoic acid were used as eluent for the ion-exclusion chromatographic separation of aliphatic carboxylic acids with different pKa values and hydrophobicity on a polymethacrylate-based weakly acidic cation-exchange resin in the H+ form. With increasing concentration of β-cyclodextrin in the eluent, the retention times of the carboxylic acids decreased due to the increased hydrophilicity of the polymethacrylate-based cation-exchange resin surface from the adsorption of OH groups of β-cyclodextrin. Moreover, the eluent background conductivity decreased with increasing concentration of β-cyclodextrin in 1 mM benzoic acid, which could result in higher sensitivity for conductimetric detection. The ion-exclusion chromatographic separation of carboxylic acids with high resolution and sensitivity was accomplished successfully by elution with a 1 mM benzoic acid-10 mM cyclodextrin solution without chemical suppression. © 2003 Elsevier Science B.V. All rights reserved.

History

Publication title

Journal of Chromatography A

Volume

997

Issue

1-2

Pagination

127-132

ISSN

0021-9673

Department/School

School of Natural Sciences

Publisher

Elsevier Science BV

Place of publication

Amsterdam, Netherlands

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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