eCite Digital Repository

Ion-exclusion chromatography with conductimetric detection of aliphatic carboxylic acids on a weakly acidic cation-exchange resin by elution with benzoic acid-beta-cyclodextrin

Citation

Tanaka, K and Mori, M and Xu, Q and Halaleh, MIH and Ikedo, M and Taoda, H and Hu, W and Hasebe, K and Fritz, J and Haddad, PR, Ion-exclusion chromatography with conductimetric detection of aliphatic carboxylic acids on a weakly acidic cation-exchange resin by elution with benzoic acid-beta-cyclodextrin, Journal of Chromatography A, 997, (1-2) pp. 127-132. ISSN 0021-9673 (2003) [Refereed Article]

DOI: doi:10.1016/S0021-9673(03)00545-4

Abstract

In this study, an aqueous solution consisting of benzoic acid with low background conductivity and β-cyclodextrin (β-CD) of hydrophilic nature and the inclusion effect to benzoic acid were used as eluent for the ion-exclusion chromatographic separation of aliphatic carboxylic acids with different pKa values and hydrophobicity on a polymethacrylate-based weakly acidic cation-exchange resin in the H+ form. With increasing concentration of β-cyclodextrin in the eluent, the retention times of the carboxylic acids decreased due to the increased hydrophilicity of the polymethacrylate-based cation-exchange resin surface from the adsorption of OH groups of β-cyclodextrin. Moreover, the eluent background conductivity decreased with increasing concentration of β-cyclodextrin in 1 mM benzoic acid, which could result in higher sensitivity for conductimetric detection. The ion-exclusion chromatographic separation of carboxylic acids with high resolution and sensitivity was accomplished successfully by elution with a 1 mM benzoic acid-10 mM cyclodextrin solution without chemical suppression. © 2003 Elsevier Science B.V. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Tanaka, K (Dr Kazuhiko Tanaka)
Author:Haddad, PR (Professor Paul Haddad)
ID Code:27354
Year Published:2003
Web of Science® Times Cited:15
Deposited By:Chemistry
Deposited On:2003-08-01
Last Modified:2011-10-24
Downloads:0

Repository Staff Only: item control page