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(R,S)-Salbutamol plasma concentrations in severe asthma
Citation
Jacobson, GA and Chong, FV and Wood-Baker, R, (R,S)-Salbutamol plasma concentrations in severe asthma, Journal of Clinical Pharmacy and Therapeutics, 28, (3) pp. 235-238. ISSN 0269-4727 (2003) [Refereed Article]
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Copyright Statement
The definitive published version is available online at: http://onlinelibrary.wiley.com/
Official URL: http://onlinelibrary.wiley.com/
DOI: doi:10.1046/j.1365-2710.2003.00483.x
Abstract
Objective: Salbutamol is commonly delivered as a racemic mixture of pharmacologically active (R)-salbutamol and inactive (S)-salbutamol. This study investigated inactive (S)- and active (R)-salbutamol plasma levels and their relationship to dose in patients with severe asthma.
Methods: Basic demographics, racemic-salbutamol dose in the preceding 24 h, lung function tests at baseline and 1 h, and a 10 mL plasma sample were obtained from subjects presenting to the Department of Emergency Medicine with acute asthma. Plasma determinations were carried out using an LC-MS assay with solid phase extraction.
Results: All patients (n = 5) had detectable levels of drug in plasma with range of 0·9–7·7 and 4·7–27·4 ng/mL for (R)-salbutamol and (S)-salbutamol respectively. These were correlated to total racemic salbutamol dose. The range of the (S) : (R) ratio was 2·0–5·2, with (R)-salbutamol representing 16–33% of the total plasma concentration, which did not correlate with total salbutamol dose.
Conclusion: Only a small fraction of total plasma salbutamol concentration was found to consist of active enantiomer in patients with an acute severe exacerbation of asthma actively undergoing treatment with racemic-salbutamol. As a result of the possible contribution of (S)-salbutamol to poor asthma control further enantioselective investigations are warranted in severe asthma.
Item Details
Item Type: | Refereed Article |
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Keywords: | asthma;chiral;enantiomer;salbutamol |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Respiratory diseases |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Jacobson, GA (Professor Glenn Jacobson) |
UTAS Author: | Chong, FV (Miss Fui Chong) |
UTAS Author: | Wood-Baker, R (Professor Richard Wood-Baker) |
ID Code: | 27131 |
Year Published: | 2003 |
Web of Science® Times Cited: | 7 |
Deposited By: | Medicine |
Deposited On: | 2003-08-01 |
Last Modified: | 2011-05-30 |
Downloads: | 0 |
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