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(R,S)-Salbutamol plasma concentrations in severe asthma

Citation

Jacobson, GA and Chong, FV and Wood-Baker, R, (R,S)-Salbutamol plasma concentrations in severe asthma, Journal of Clinical Pharmacy and Therapeutics, 28, (3) pp. 235-238. ISSN 0269-4727 (2003) [Refereed Article]

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The definitive published version is available online at: http://onlinelibrary.wiley.com/

Official URL: http://onlinelibrary.wiley.com/

DOI: doi:10.1046/j.1365-2710.2003.00483.x

Abstract

Objective: Salbutamol is commonly delivered as a racemic mixture of pharmacologically active (R)-salbutamol and inactive (S)-salbutamol. This study investigated inactive (S)- and active (R)-salbutamol plasma levels and their relationship to dose in patients with severe asthma. Methods: Basic demographics, racemic-salbutamol dose in the preceding 24 h, lung function tests at baseline and 1 h, and a 10 mL plasma sample were obtained from subjects presenting to the Department of Emergency Medicine with acute asthma. Plasma determinations were carried out using an LC-MS assay with solid phase extraction. Results: All patients (n = 5) had detectable levels of drug in plasma with range of 0򊲭7 and 4򊋐74 ng/mL for (R)-salbutamol and (S)-salbutamol respectively. These were correlated to total racemic salbutamol dose. The range of the (S) : (R) ratio was 2򈁟2, with (R)-salbutamol representing 1633% of the total plasma concentration, which did not correlate with total salbutamol dose. Conclusion: Only a small fraction of total plasma salbutamol concentration was found to consist of active enantiomer in patients with an acute severe exacerbation of asthma actively undergoing treatment with racemic-salbutamol. As a result of the possible contribution of (S)-salbutamol to poor asthma control further enantioselective investigations are warranted in severe asthma.

Item Details

Item Type:Refereed Article
Keywords:asthma;chiral;enantiomer;salbutamol
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Jacobson, GA (Dr Glenn Jacobson)
Author:Chong, FV (Miss Fui Chong)
Author:Wood-Baker, R (Professor Richard Wood-Baker)
ID Code:27131
Year Published:2003
Web of Science® Times Cited:5
Deposited By:Medicine (Discipline)
Deposited On:2003-08-01
Last Modified:2011-05-30
Downloads:0

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