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Dietary Microbial Toxins and Type 1 Diabetes

Citation

Myers, MA and Hettiarachchi, K and Ludeman, J and Wilson, A and Wilson, CR and Zimmet, PZ, Dietary Microbial Toxins and Type 1 Diabetes, Annals of the New York Academy of Science, 1005 pp. 418-422. ISSN 0077-8923 (2003) [Refereed Article]

DOI: doi:10.1196/annals.1288.071

Abstract

Toxins may promote type 1 diabetes by modifying or damaging the β cell causing release of autoantigens. Streptomyces is a common soil bacterium that produces many toxic compounds. Some Streptomyces can infect vegetables, raising the possibility of dietary exposure to toxins. We aimed to identify toxins that erode cellular proton gradients in extracts of Streptomyces and infested vegetables and to establish the effect of low doses of these toxins on pancreatic islets in mice. The vacuolar ATPase inhibitors, bafilomycin and concanamycin, and the ionophore, nigericin, were identified in extracts from 4 of 13 Streptomyces isolated from infested potatoes and in potatoes themselves. Injection of bafilomycin A1 into mice impaired glucose tolerance, reduced islet size, and decreased relative β cell mass. Thus, exposure to small quantities of bafilomycin in the diet may contribute to the cause of type 1 diabetes.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Wilson, A (Mrs Annabel Wilson)
Author:Wilson, CR (Associate Professor Calum Wilson)
ID Code:26505
Year Published:2003
Web of Science® Times Cited:29
Deposited By:Agricultural Science
Deposited On:2003-08-01
Last Modified:2011-09-20
Downloads:0

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