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Tachykinin receptor (NK1, NK2, NK3) binding sites in the rat caudal brainstem following neonatal capsaicin administration

Citation

Geraghty, DP and Mazzone, SB, Tachykinin receptor (NK1, NK2, NK3) binding sites in the rat caudal brainstem following neonatal capsaicin administration, Brain Research, 979, (979) pp. 230-234. ISSN 0006-8993 (2003) [Refereed Article]


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DOI: doi:10.1016/S0006-8993(03)02871-3

Abstract

Binding of [125I]-Bolton–Hunter substance P ([125I]-BHSP), [125I]-neurokinin A and [3H]-senktide to tachykinin NK1, NK2 and NK3 receptors, respectively, was examined in caudal brainstem sections of 10-week-old rats pretreated as neonates (P2) with capsaicin (50 mg/kg, s.c.) or vehicle. [125I]-BHSP binding was localised to the nucleus of the solitary tract (NTS), hypoglossal nucleus and inferior olivary complex, whereas [125I]-neurokinin A and [3H]-senktide binding were confined to the NTS. The distribution and density of binding sites were similar in vehicle- and capsaicin-pretreated rats, suggesting that sensory neuron ablation by neonatal capsaicin does not affect tachykinin receptor numbers in the rat caudal brainstem.

Item Details

Item Type:Refereed Article
Keywords:Neurotransmitters, modulators, transporters, and receptors, Receptor modulation, up- and down-regulation
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Basic Pharmacology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Geraghty, DP (Professor Dominic Geraghty)
Author:Mazzone, SB (Mr Stuart Brett Mazzone)
ID Code:26368
Year Published:2003
Web of Science® Times Cited:7
Deposited By:Health Sciences A
Deposited On:2003-08-01
Last Modified:2011-06-14
Downloads:0

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