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Exposure to Automotive Pollution Increases Plasma Susceptibility to Oxidation
journal contribution
posted on 2023-05-16, 14:04 authored by James SharmanJames Sharman, Coombes, JS, Dominic Geraghty, Fraser, DILow-density lipoprotein oxidation is implicated in the development of atherosclerosis. Plasma susceptibility to oxidation may be used as a marker of low-density lipoprotein oxidation and thus predict atherosclerotic risk. In this study the authors investigated the relationship between plasma susceptibility to oxidation and exposure to automotive pollution in a group of automobile mechanics (n = 16) exposed to high levels of automotive pollution, vs. matched controls (n = 13). The authors induced plasma oxidation by a free radical initiator and they determined susceptibility to oxidation by (1) change in absorbance at 234 nm, (2) lag time to conjugated diene formation, and (3) linear slope of the oxidation curve. Mechanics had significantly higher values (mean ± standard error) for change in absorbance (1.60 ± 0.05 vs. 1.36 ± 0.05; p < .002), and slope (1.6 × 10-3 ± 0.1 × 10-3 vs. 1.3 × 10-3 ± 0.1 × 10-3; p < .001), compared with controls. These results indicate that regular exposure to automotive pollutants increases plasma susceptibility to oxidation and may, in the long term, increase the risk of developing atherosclerosis.
History
Publication title
Archives of Environmental HealthVolume
57Issue
6Pagination
536-540ISSN
0003-9896Department/School
Menzies Institute for Medical ResearchPublisher
Heldref PublicationsPlace of publication
Washington DCRepository Status
- Restricted