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Exposure to Automotive Pollution Increases Plasma Susceptibility to Oxidation


Sharman, JE and Coombes, JS and Geraghty, DP and Fraser, DI, Exposure to Automotive Pollution Increases Plasma Susceptibility to Oxidation, Archives of Environmental Health, 57, (6) pp. 536-540. ISSN 0003-9896 (2002) [Refereed Article]

DOI: doi:10.1080/00039890209602085


Low-density lipoprotein oxidation is implicated in the development of atherosclerosis. Plasma susceptibility to oxidation may be used as a marker of low-density lipoprotein oxidation and thus predict atherosclerotic risk. In this study the authors investigated the relationship between plasma susceptibility to oxidation and exposure to automotive pollution in a group of automobile mechanics (n = 16) exposed to high levels of automotive pollution, vs. matched controls (n = 13). The authors induced plasma oxidation by a free radical initiator and they determined susceptibility to oxidation by (1) change in absorbance at 234 nm, (2) lag time to conjugated diene formation, and (3) linear slope of the oxidation curve. Mechanics had significantly higher values (mean ± standard error) for change in absorbance (1.60 ± 0.05 vs. 1.36 ± 0.05; p < .002), and slope (1.6 × 10-3 ± 0.1 × 10-3 vs. 1.3 × 10-3 ± 0.1 × 10-3; p < .001), compared with controls. These results indicate that regular exposure to automotive pollutants increases plasma susceptibility to oxidation and may, in the long term, increase the risk of developing atherosclerosis.

Item Details

Item Type:Refereed Article
Research Division:Environmental Sciences
Research Group:Environmental management
Research Field:Environmental assessment and monitoring
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Sharman, JE (Professor James Sharman)
UTAS Author:Geraghty, DP (Professor Dominic Geraghty)
UTAS Author:Fraser, DI (Mr David Fraser)
ID Code:26363
Year Published:2002
Web of Science® Times Cited:17
Deposited By:Health Sciences A
Deposited On:2003-08-01
Last Modified:2011-07-13

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