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Nerve growth factor promotes olfactory axonal elongation

Citation

Martin, LV and Weston, S and West, AK and Chuah, MI, Nerve growth factor promotes olfactory axonal elongation, Neuroreport, 13, (5) pp. 621-625. ISSN 0959-4965 (2002) [Refereed Article]

DOI: doi:10.1097/00001756-200204160-00017

Abstract

An explant culture system was used to test the effect of nerve growth factor (NGF) on olfactory axonal elongation. Statistical analysis showed that exogenously applied NGF (50 ng/ml) significantly enhanced olfactory neurite elongation from E14 rat olfactory epithelial explants (p = 0.025). Immunostaining showed that the neurites expressed activeTrkA receptors and that S-100-positive ensheathing cells were also present. In a separate experiment, immunoassay confirmed that following a growth period of 72 h, E14 presumptive olfactory bulb expressed and secreted NGF into the culture medium. The results indicate that during ontogeny, the olfactory bulb secretes NGF which binds to olfactory axons and facilitates their elongation. © 2002 Lippincott Williams & Wilkins.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:Martin, LV (Miss Lee Martin)
Author:Weston, S (Mr Steven Weston)
Author:West, AK (Professor Adrian West)
Author:Chuah, MI (Dr Inn Chuah)
ID Code:25130
Year Published:2002
Web of Science® Times Cited:13
Deposited By:Anatomy and Physiology
Deposited On:2002-08-01
Last Modified:2003-04-01
Downloads:0

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