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The Microvasculature in Insulin Resistance and Type 2 Diabetes

Citation

Clark, MG and Barrett, EJ and Wallis, MG and Vincent, MA and Rattigan, S, The Microvasculature in Insulin Resistance and Type 2 Diabetes, Seminars in Vascular Medicine, 2, (1) pp. 21-31. ISSN 1528-9648 (2002) [Refereed Article]

DOI: doi:10.1055/s-2002-23506

Abstract

Insulin resistance of muscle has been attributed to impairment of elements of insulin signaling, glucose transport, and/or metabolism within the muscle cells. This article explores the notion that a component of insulin resistance in vivo may result from impaired hemodynamic effects of this hormone to facilitate access to the muscle cells for itself and other nutrients, including glucose. In chronic situations this may manifest as a decreased capillary density of muscle, but in the acute, there may be impaired mechanisms for increasing total limb blood flow or for achieving optimal microvascular perfusion. Newly developed techniques show that insulin acts to recruit muscle capillary flow to enhance microvascular perfusion in animals and humans. This microvascular effect of insulin correlates closely with muscle glucose uptake, is independent of increases in bulk blood flow, and is impaired in obese insulin-resistant patients. Similarly, there are impaired vasodilatory responses in the skin of diabetic subjects.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Clark, MG (Professor Michael Clark)
Author:Wallis, MG (Ms Michelle Gaye Wallis)
Author:Rattigan, S (Professor Stephen Rattigan)
ID Code:24674
Year Published:2002
Deposited By:Biochemistry
Deposited On:2002-08-01
Last Modified:2011-11-28
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