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Vasoconstrictor-mediated thermogenesis present in perfused skeletal muscle but absent from perfused heart

Citation

DiMaria, CA and Rattigan, S and Clark, MG, Vasoconstrictor-mediated thermogenesis present in perfused skeletal muscle but absent from perfused heart, Journal of Thermal Biology, 27, (2) pp. 151-158. ISSN 0306-4565 (2002) [Refereed Article]

DOI: doi:10.1016/S0306-4565(01)00078-X

Abstract

Resting muscle thermogenesis as controlled by vasocontrictors was compared in rat hindlimb and cardiac muscle. An α-adrenergic agonist combination of phenylephrine + atenolol increased oxygen uptake and perfusion pressure in the constant flow hindlimb and neither increase was blocked by 10 μM tetrodotoxin. The same adrenergic combination also increased oxygen uptake and perfusion pressure in the perfused heart but the former along with beating was Completely blocked by tetrodotoxin. Vasoconstriction by phenylephrine occurs in the heart but is not linked to thermogenic increases as in hindlimb, implying that all metabolic energy in heart is conserved for contractile activity. The findings highlight a fundamental difference between skeletal and cardiac muscle. © 2002 Elsevier Science Ltd. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Cell Metabolism
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:DiMaria, CA (Ms Carla Alexandra DiMaria)
Author:Rattigan, S (Professor Stephen Rattigan)
Author:Clark, MG (Professor Michael Clark)
ID Code:24670
Year Published:2002
Web of Science® Times Cited:2
Deposited By:Biochemistry
Deposited On:2002-08-01
Last Modified:2011-11-17
Downloads:0

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