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Cortical excitability of psychiatric disorders: reduced post-exercise facilitation in depression compared to schizophrenia and controls

Citation

Reid, P and Daniels, BA and Rybak, M and Turnier-Shea, Y and Pridmore, S, Cortical excitability of psychiatric disorders: reduced post-exercise facilitation in depression compared to schizophrenia and controls, Australian and New Zealand Journal of Psychiatry, 36, (5) pp. 669-673. ISSN 0004-8674 (2002) [Refereed Article]

DOI: doi:10.1046/j.1440-1614.2002.01082.x

Abstract

Objective: In normal subjects, motor evoked potentials (MEPs) produced by transcranial magnetic stimulation (TMS) from the motor cortex are increased after non-fatiguing exercise of hand muscles. This phenomenon is called post-exercise facilitation. This study aims to test the hypothesis that psychiatric syndromes (major depressive episode, schizophrenia) have different levels of post-exercise facilitation compared to controls. Methods: Patients with DSM-IV major depressive episode (six female, four male), schizophrenia (two female, nine male) and a control group (nine female, four male) participated. MEPs were elicited pre- and post-exercise from the contralateral abductor pollicis brevis by TMS over the primary motor cortex. Results: Post-exercise facilitation expressed as a percentage of baseline was 510% in controls, 110% in depression and 190% in schizophrenia. There were significant differences in patients with depression and schizophrenia compared to controls (p = 0.0001, p = 0.0008). Conclusions: Post-exercise facilitation was reduced in depression and schizophrenia, suggesting impaired cortical excitability in these disorders. Further studies may discriminate between the two groups.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Psychiatry (incl. Psychotherapy)
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Mental Health
Author:Reid, P (Dr Philip Reid)
Author:Daniels, BA (Dr Brett Daniels)
Author:Rybak, M (Dr Marzena Rybak)
Author:Turnier-Shea, Y (Dr Yvonne Turnier-Shea)
Author:Pridmore, S (Professor Saxby Pridmore)
ID Code:24485
Year Published:2002
Web of Science® Times Cited:11
Deposited By:Psychiatry
Deposited On:2002-08-01
Last Modified:2003-04-02
Downloads:0

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