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Cortical excitability of psychiatric disorders: reduced post-exercise facilitation in depression compared to schizophrenia and controls

journal contribution
posted on 2023-05-16, 13:35 authored by Reid, P, Daniels, BA, Rybak, M, Turnier-Shea, Y, Saxby PridmoreSaxby Pridmore
Objective: In normal subjects, motor evoked potentials (MEPs) produced by transcranial magnetic stimulation (TMS) from the motor cortex are increased after non-fatiguing exercise of hand muscles. This phenomenon is called post-exercise facilitation. This study aims to test the hypothesis that psychiatric syndromes (major depressive episode, schizophrenia) have different levels of post-exercise facilitation compared to controls. Methods: Patients with DSM-IV major depressive episode (six female, four male), schizophrenia (two female, nine male) and a control group (nine female, four male) participated. MEPs were elicited pre- and post-exercise from the contralateral abductor pollicis brevis by TMS over the primary motor cortex. Results: Post-exercise facilitation expressed as a percentage of baseline was 510% in controls, 110% in depression and 190% in schizophrenia. There were significant differences in patients with depression and schizophrenia compared to controls (p = 0.0001, p = 0.0008). Conclusions: Post-exercise facilitation was reduced in depression and schizophrenia, suggesting impaired cortical excitability in these disorders. Further studies may discriminate between the two groups.

History

Publication title

Australian and New Zealand Journal of Psychiatry

Volume

36

Issue

5

Pagination

669-673

ISSN

0004-8674

Department/School

Tasmanian School of Medicine

Publisher

Blackwell Publishing Asia

Place of publication

Victoria

Repository Status

  • Restricted

Socio-economic Objectives

Mental health

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