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The effects of single-dose lorazepam on memory and behavioural learning
journal contribution
posted on 2023-05-16, 13:30 authored by Allison MatthewsAllison Matthews, Kenneth KirkbyKenneth Kirkby, Martin, FThe sensitivity of several neurophysiological and cognitive tests to different levels of hypoxia was investigated. Cerebral hypoxia in healthy volunteers may be a disease model for dementia or other forms of brain dysfunction. Twelve healthy subjects were included in a randomized, single-blind, placebo-controlled, three-period cross-over trial. They received three air/N 2 gas mixtures via mask breathing [aimed at peripheral oxygen saturation (SPO 2 ) values of > 97% (placebo), 90% and 80%, with normal end-tidal CO 2 ]. Central nervous system effects were tested regularly for 130 min by saccadic and smooth pursuit eye movements, electro-encephalogram, visual analogue scales and cognitive tests. Treatments were well tolerated. Compared to SPO 2 90%, SPO 2 80% reduced saccadic peak velocity by 16.4 /s [confidence interval (CI) -26.3, -6.4], increased occipital delta power by 14.3% (CI 3.6, 25.1), and significantly increased most cognitive reaction times. SPO 2 80% also decreased correct responses for the binary choice task and serial word recognition [-1.3 (-2.2, -0.3) and -3.5 (-6.2, -0.8), respectively] compared to SPO 2 90%. Cognitive performance was decreased by SPO 2 80% and increased by SPO 2 90% compared to placebo. Sensitive effect measurements can be identified for these interventions. The applicability as a model for cognitive impairment should be investigated further.
History
Publication title
Journal of PsychopharmacologyVolume
16Issue
4Pagination
343-352ISSN
0269-8811Department/School
School of Psychological SciencesPublisher
SAGE Publications LtdPlace of publication
LondonRepository Status
- Restricted