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The effects of single-dose lorazepam on memory and behavioural learning


Matthews, AJ and Kirkby, KC and Martin, F, The effects of single-dose lorazepam on memory and behavioural learning, Journal of Psychopharmacology, 16, (4) pp. 343-352. ISSN 0269-8811 (2002) [Refereed Article]

DOI: doi:10.1177/026988110201600408


The sensitivity of several neurophysiological and cognitive tests to different levels of hypoxia was investigated. Cerebral hypoxia in healthy volunteers may be a disease model for dementia or other forms of brain dysfunction. Twelve healthy subjects were included in a randomized, single-blind, placebo-controlled, three-period cross-over trial. They received three air/N 2 gas mixtures via mask breathing [aimed at peripheral oxygen saturation (SPO 2 ) values of > 97% (placebo), 90% and 80%, with normal end-tidal CO 2 ]. Central nervous system effects were tested regularly for 130 min by saccadic and smooth pursuit eye movements, electro-encephalogram, visual analogue scales and cognitive tests. Treatments were well tolerated. Compared to SPO 2 90%, SPO 2 80% reduced saccadic peak velocity by 16.4 /s [confidence interval (CI) -26.3, -6.4], increased occipital delta power by 14.3% (CI 3.6, 25.1), and significantly increased most cognitive reaction times. SPO 2 80% also decreased correct responses for the binary choice task and serial word recognition [-1.3 (-2.2, -0.3) and -3.5 (-6.2, -0.8), respectively] compared to SPO 2 90%. Cognitive performance was decreased by SPO 2 80% and increased by SPO 2 90% compared to placebo. Sensitive effect measurements can be identified for these interventions. The applicability as a model for cognitive impairment should be investigated further.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Mental health services
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Behaviour and health
UTAS Author:Matthews, AJ (Dr Allison Matthews)
UTAS Author:Kirkby, KC (Professor Kenneth Kirkby)
UTAS Author:Martin, F (Associate Professor Frances Martin)
ID Code:24220
Year Published:2002
Web of Science® Times Cited:34
Deposited By:Psychology
Deposited On:2002-08-01
Last Modified:2003-05-08

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