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Salicin was administered orally to six brushtail possums by incorporation in food for six days at three dose levels (0.05, 0.5, and 1.5% wet weight), giving mean ± SD daily intakes of 0.31 ± 0.09, 2.76 ± 0.75, and 6.04 ± 1.12 mmol salicin. Metabolites were identified by mass spectrometry and assayed by HPLC. Salicyl alcohol glucuronide accounted for 56–64% of urinary metabolites over the three doses, salicyluric acid 15–26%, salicin 10–18%, and there were smaller amounts of free (2–4%) and conjugated (0–6%) salicylic acid. ,2-Dihydroxyphenylpropionic acid was a minor metabolite. The hydrolysis of dietary salicin enabled reconjugation of its aglycone, salicyl alcohol, with a more polar sugar, glucuronic acid, thus enhancing its renal excretion and resulting in little net loss of substrates for conjugation and a low measurable metabolic cost of excretion.

Item Type:	Refereed Article
Keywords:	Salicin - metabolism - glucose conjugate - plant secondary metabolite - common brushtail possum - detoxication - costs
Research Division:	Biological Sciences
Research Group:	Ecology
Research Field:	Terrestrial Ecology
Objective Division:	Environment
Objective Group:	Flora, Fauna and Biodiversity
Objective Field:	Forest and Woodlands Flora, Fauna and Biodiversity
Author:	McLean, SR (Professor Stuart McLean)
Author:	Pass, GJ (Ms Georgia Jane Pass)
Author:	Brandon, S (Mrs Susan Brandon)
Author:	Davies, NW (Associate Professor Noel Davies)
ID Code:	22864
Year Published:	2001
Web of Science® Times Cited:	18
Deposited By:	Pharmacy
Deposited On:	2001-08-01
Last Modified:	2011-05-31
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