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Does excretion of secondary metabolites always involve a measurable metabolic cost? Fate of plant antifeedant salicin in common brushtail possum, Trichosurus vulpecula

Citation

McLean, SR and Pass, GJ and Foley, WJ and Brandon, S and Davies, NW, Does excretion of secondary metabolites always involve a measurable metabolic cost? Fate of plant antifeedant salicin in common brushtail possum, Trichosurus vulpecula, Journal of Chemical Ecology, 27, (6) pp. 1077-1089. ISSN 0098-0331 (2001) [Refereed Article]


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DOI: doi:10.1023/A:1010303726439

Abstract

Salicin was administered orally to six brushtail possums by incorporation in food for six days at three dose levels (0.05, 0.5, and 1.5% wet weight), giving mean SD daily intakes of 0.31 0.09, 2.76 0.75, and 6.04 1.12 mmol salicin. Metabolites were identified by mass spectrometry and assayed by HPLC. Salicyl alcohol glucuronide accounted for 5664% of urinary metabolites over the three doses, salicyluric acid 1526%, salicin 1018%, and there were smaller amounts of free (24%) and conjugated (06%) salicylic acid. ,2-Dihydroxyphenylpropionic acid was a minor metabolite. The hydrolysis of dietary salicin enabled reconjugation of its aglycone, salicyl alcohol, with a more polar sugar, glucuronic acid, thus enhancing its renal excretion and resulting in little net loss of substrates for conjugation and a low measurable metabolic cost of excretion.

Item Details

Item Type:Refereed Article
Keywords:Salicin - metabolism - glucose conjugate - plant secondary metabolite - common brushtail possum - detoxication - costs
Research Division:Biological Sciences
Research Group:Ecology
Research Field:Terrestrial Ecology
Objective Division:Environment
Objective Group:Flora, Fauna and Biodiversity
Objective Field:Forest and Woodlands Flora, Fauna and Biodiversity
Author:McLean, SR (Professor Stuart McLean)
Author:Pass, GJ (Ms Georgia Jane Pass)
Author:Brandon, S (Mrs Susan Brandon)
Author:Davies, NW (Associate Professor Noel Davies)
ID Code:22864
Year Published:2001
Web of Science® Times Cited:18
Deposited By:Pharmacy
Deposited On:2001-08-01
Last Modified:2011-05-31
Downloads:0

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