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Does excretion of secondary metabolites always involve a measurable metabolic cost? Fate of plant antifeedant salicin in common brushtail possum, Trichosurus vulpecula

Citation

McLean, SR and Pass, GJ and Foley, WJ and Brandon, S and Davies, NW, Does excretion of secondary metabolites always involve a measurable metabolic cost? Fate of plant antifeedant salicin in common brushtail possum, Trichosurus vulpecula, Journal of Chemical Ecology, 27, (6) pp. 1077-1089. ISSN 0098-0331 (2001) [Refereed Article]


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DOI: doi:10.1023/A:1010303726439

Abstract

Salicin was administered orally to six brushtail possums by incorporation in food for six days at three dose levels (0.05, 0.5, and 1.5% wet weight), giving mean ± SD daily intakes of 0.31 ± 0.09, 2.76 ± 0.75, and 6.04 ± 1.12 mmol salicin. Metabolites were identified by mass spectrometry and assayed by HPLC. Salicyl alcohol glucuronide accounted for 56–64% of urinary metabolites over the three doses, salicyluric acid 15–26%, salicin 10–18%, and there were smaller amounts of free (2–4%) and conjugated (0–6%) salicylic acid. ,2-Dihydroxyphenylpropionic acid was a minor metabolite. The hydrolysis of dietary salicin enabled reconjugation of its aglycone, salicyl alcohol, with a more polar sugar, glucuronic acid, thus enhancing its renal excretion and resulting in little net loss of substrates for conjugation and a low measurable metabolic cost of excretion.

Item Details

Item Type:Refereed Article
Keywords:Salicin - metabolism - glucose conjugate - plant secondary metabolite - common brushtail possum - detoxication - costs
Research Division:Biological Sciences
Research Group:Ecology
Research Field:Terrestrial ecology
Objective Division:Environmental Management
Objective Group:Terrestrial systems and management
Objective Field:Terrestrial biodiversity
UTAS Author:McLean, SR (Professor Stuart McLean)
UTAS Author:Pass, GJ (Ms Georgia Jane Pass)
UTAS Author:Brandon, S (Mrs Susan Brandon)
UTAS Author:Davies, NW (Associate Professor Noel Davies)
ID Code:22864
Year Published:2001
Web of Science® Times Cited:18
Deposited By:Pharmacy
Deposited On:2001-08-01
Last Modified:2011-05-31
Downloads:0

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