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Does excretion of secondary metabolites always involve a measurable metabolic cost? Fate of plant antifeedant salicin in common brushtail possum, Trichosurus vulpecula
Citation
McLean, SR and Pass, GJ and Foley, WJ and Brandon, S and Davies, NW, Does excretion of secondary metabolites always involve a measurable metabolic cost? Fate of plant antifeedant salicin in common brushtail possum, Trichosurus vulpecula, Journal of Chemical Ecology, 27, (6) pp. 1077-1089. ISSN 0098-0331 (2001) [Refereed Article]
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DOI: doi:10.1023/A:1010303726439
Abstract
Salicin was administered orally to six brushtail possums by incorporation in food for six days at three dose levels (0.05, 0.5, and 1.5% wet weight), giving mean ± SD daily intakes of 0.31 ± 0.09, 2.76 ± 0.75, and 6.04 ± 1.12 mmol salicin. Metabolites were identified by mass spectrometry and assayed by HPLC. Salicyl alcohol glucuronide accounted for 56–64% of urinary metabolites over the three doses, salicyluric acid 15–26%, salicin 10–18%, and there were smaller amounts of free (2–4%) and conjugated (0–6%) salicylic acid. ,2-Dihydroxyphenylpropionic acid was a minor metabolite. The hydrolysis of dietary salicin enabled reconjugation of its aglycone, salicyl alcohol, with a more polar sugar, glucuronic acid, thus enhancing its renal excretion and resulting in little net loss of substrates for conjugation and a low measurable metabolic cost of excretion.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Salicin - metabolism - glucose conjugate - plant secondary metabolite - common brushtail possum - detoxication - costs |
| Research Division: | Biological Sciences |
| Research Group: | Ecology |
| Research Field: | Terrestrial Ecology |
| Objective Division: | Environment |
| Objective Group: | Flora, Fauna and Biodiversity |
| Objective Field: | Forest and Woodlands Flora, Fauna and Biodiversity |
| UTAS Author: | McLean, SR (Professor Stuart McLean) |
| UTAS Author: | Pass, GJ (Ms Georgia Jane Pass) |
| UTAS Author: | Brandon, S (Mrs Susan Brandon) |
| UTAS Author: | Davies, NW (Associate Professor Noel Davies) |
| ID Code: | 22864 |
| Year Published: | 2001 |
| Web of Science® Times Cited: | 18 |
| Deposited By: | Pharmacy |
| Deposited On: | 2001-08-01 |
| Last Modified: | 2011-05-31 |
| Downloads: | 0 |
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