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Monotreme IGF2 expression and ancestral origin of genomic imprinting

Citation

Killian, JK and Nolan, CM and Stewart, NJ and Munday, BL and Andersen, NA and Nicol, SC and Jirtle, RL, Monotreme IGF2 expression and ancestral origin of genomic imprinting, Journal of Experimental Zoology (Molecular Development & Evolution), 291, (2) pp. 205-212. ISSN 0022-104X (2001) [Refereed Article]

DOI: doi:10.1002/jez.1070

Abstract

IGF2 (insulin-like growth factor 2) and M6P / IGF2R (mannose 6-phosphate/insulin-like growth factor 2 receptor) are imprinted in marsupials and eutherians but not in birds. These results along with the absence of M6P / IGF2R imprinting in the egg-laying monotremes indicate that the parental imprinting of fetal growth-regulatory genes may be unique to viviparous mammals. In this investigation, we have cloned IGF2 from two monotreme mammals, the platypus and echidna, to further investigate the origin of imprinting. We report herein that like M6P / IGF2R, IGF2 is not imprinted in monotremes. Thus, although IGF2 encodes for a highly conserved growth factor in chordates, it is only imprinted in therian mammals. These findings support a concurrent origin of IGF2 and M6P / IGF2R imprinting in the late Jurassic/early Cretaceous period. The absence of imprinting in monotremes, despite apparent interparental conflicts over maternal - offspring exchange, argues that a fortuitous congruency of genetic and epigenetic events may have limited the phylogenetic breadth of genomic imprinting to therian mammals. © 2001 Wiley-Liss, Inc.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Population, Ecological and Evolutionary Genetics
Objective Division:Environment
Objective Group:Flora, Fauna and Biodiversity
Objective Field:Flora, Fauna and Biodiversity of environments not elsewhere classified
Author:Stewart, NJ (Dr Niall Stewart)
Author:Munday, BL (Dr Barry Munday)
Author:Andersen, NA (Dr Niels Andersen)
Author:Nicol, SC (Associate Professor Stewart Nicol)
ID Code:22581
Year Published:2001
Web of Science® Times Cited:102
Deposited By:Health Sciences A
Deposited On:2001-08-01
Last Modified:2011-08-03
Downloads:0

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