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Fast separation of pyrimidine derivatives by capillary electrochromatography on ion-exchange/reversed-phase mixed-mode stationary phases

Citation

Klampfl, CW and Buchberger, W and Haddad, PR, Fast separation of pyrimidine derivatives by capillary electrochromatography on ion-exchange/reversed-phase mixed-mode stationary phases, Journal of Chromatography A, 911, (2) pp. 277-283. ISSN 0021-9673 (2001) [Refereed Article]


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DOI: doi:10.1016/S0021-9673(01)00515-5

Abstract

This work describes the use of mixed–mode stationary phases which exhibit both strong ion-exchange (either cation-exchange, SCX, or anion-exchange, SAX) and reversed-phase chromatographic characteristics in capillary electrochromatographic separations of pyrimidine derivatives. Different packing materials, namely C6, SCX/C6 and SAX/C6, were compared and the influence of the composition of the carrier electrolyte (concentration of acetonitrile and pH) on the retention behavior of the selected solutes was investigated. A separation of all eight pyrimidine derivatives could be obtained on a 6.5 cm column packed with the SAX/C6 stationary phase in less than 3 min, with good peak shapes and efficiencies in the range 39 000 to 81 000 plates per meter.

Item Details

Item Type:Refereed Article
Keywords:Electrochromatography; Stationary phases, electrochromatography; Mixed-mode chromatography
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Klampfl, CW (Dr Christian Klampfl)
Author:Haddad, PR (Professor Paul Haddad)
ID Code:22191
Year Published:2001
Web of Science® Times Cited:15
Deposited By:Chemistry
Deposited On:2001-08-01
Last Modified:2010-02-08
Downloads:0

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