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Effect of a Long-acting 2-Agonist over Three Months on Airway Wall Vascular Remodeling in Asthma


Orsida, BE and Ward, C and Li, X and Bish, R and Wilson, JW and Thien, F and Walters, EH, Effect of a Long-acting a2-Agonist over Three Months on Airway Wall Vascular Remodeling in Asthma, American Journal of Respiratory and Critical Care Medicine, 164, (1) pp. 117-121. ISSN 1073-449X (2001) [Refereed Article]

DOI: doi:10.1164/ajrccm.164.1.2006003


There are few data regarding the potential effects of antiasthma treatment on indices of airway remodeling, such as the increased subepithelial airway vascularity in patients with asthma. We studied 45 symptomatic subjects with asthma who were receiving treatment with low dose inhaled corticosteroids (ICS) (range 200-500 μg twice a day) and 28 normal subjects without asthma as a control population. Subjects underwent bronchoscopy with airway biopsy and subjects with asthma were then randomized to receive supplementary inhaled salmeterol 50 μg twice a day, fluticasone propionate 100 μg twice a day, or placebo for 3 mo in addition to their baseline ICS. Biopsy of the airway was then repeated. The biopsies were analyzed for vascular structures in the subepithelial lamina propria. Sufficient biopsy material was available for analysis of vascularity in 34 of the subjects with asthma and 28 of the normal subjects. We confirmed that airways of subjects with asthma had a significant increase in the number of vessels/mm 2 of lamina propria compared with airways of normal subjects (524 ± 137 vessels/mm 2 , n = 34 versus 425 ± 130 vessels/mm 2 , n = 28; p = 0.004). There was a decrease in the density of vessels of lamina propria after treatment only in the salmeterol group compared with baseline (before, 535 ± 153 vessels/mm 2 versus after, 400 ± 142 vessels/mm 2 ; n = 12; p = 0.04). There was no significant change within the fluticasone (n = 11) or placebo (n = 11) treatment groups, but also no significant differences between the groups. Notably, no treatment was associated with increased airway wall vascularity. The demonstrated fall in vessel number within the salmeterol-treated group may suggest an advantageous effect of long-acting β 2 -agonists on this manifestation of airway remodeling over the 3-mo time scale of this study, which is complementary to the action of ICS on airway vascularity.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Walters, EH (Professor Haydn Walters)
ID Code:21836
Year Published:2001
Web of Science® Times Cited:102
Deposited By:Medicine
Deposited On:2001-08-01
Last Modified:2002-07-04

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