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Malignant thymic carcinoid is not prevented by transcervical thymectomy in multiple endocrine neoplasia type 1
journal contribution
posted on 2023-05-16, 12:50 authored by John BurgessJohn Burgess, Giles, N, Shepherd, JJMultiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant tumour syndrome. It is characterized by primary hyperparathyroidism, pituitary neoplasia and foregut lineage neuroendocrine neo-plasia. Malignant thymic carcinoid tumours are an uncommon but important manifestation of MEN 1. Transcervical thymectomy is often advocated as prophylaxis against thymic carcinoids, although there is a paucity of evidence to support the efficacy of this procedure. This is the first report of a malignant thymic carcinoid occurring in an MEN 1 patient following prior parathyroidectomy and transcervical thymectomy. It is concluded that transcervical thymectomy does not reliably provide prophylaxis against thymic carcinoid.
History
Publication title
Clinical EndocrinologyVolume
55Issue
5Pagination
689-693ISSN
0300-0664Department/School
Tasmanian School of MedicinePublisher
Blackwell Science LtdPlace of publication
Oxford, EnglandRepository Status
- Restricted