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Prevention of Autoimmunity by Induction of Cutaneous Tolerance

journal contribution
posted on 2023-05-16, 12:48 authored by Gregory WoodsGregory Woods, Chen, YP, Dewar, AL, Kathleen DohertyKathleen Doherty, Toh, BH, Muller, HK
Autoimmune gastritis develops in 20-60% of BALB/c mice following thymectomy at 3 days after birth (3dnTx). Previously we identified the gastric H+/K+ ATPase as the causative autoantigen and mapped the immunoreactive T cell epitope to a carboxyl-terminal peptide on the gastric H+/K+ ATPase β subunit. Here we show that autoimmune gastritis can be suppressed by immunizing 3dnTx mice through neonatal skin with the β subunit peptide, in combination with the contact sensitizer TNCB. When spleen cells were transferred from suppressed mice to nude mice a proportion of recipient mice developed gastritis. These results indicate that pathogenic T cells were still present in the 3dnTx mice but the absence of gastritis indicates that their activity can be regulated following induction of cutaneous tolerance by immunizing through neonatal skin. We propose that cutaneous tolerance is induced through mediation of immature Langerhans cells in neonatal skin and that this tolerance prevented the autoreactivity of pathogenic T cells. This procedure will have implications for strategies to suppress autoimmunity. © 2001 Academic Press.

History

Publication title

Cellular Immunology

Volume

207

Pagination

1-5

ISSN

0008-8749

Department/School

Tasmanian School of Medicine

Publisher

Academic Press Inc

Place of publication

California, USA

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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