In fish all the pre-requisites to mount a specific immune response are present, but the main differences from the mammalian system are that the secondary response is relatively minor and IgG is not present. In teleosts mainly IgM is present, and IgD has been recently described but its function is, as yet, unknown. However, different forms of fish IgM and its observed flexibility of structure may compensate for a lack of Ig class diversity. The innate immune response of teleosts is highly developed. Multiple forms of key constitutive and inducible components, such as lysozyme, C3, α2-macroglobulin and C-reactive protein, are present, and may enhance immune recognition. Low ambient temperature appears to have an impact on all aspects of the immune response, particularly the T-dependent specific immune response due to the non-adaptive lipid composition of T-cell membranes. Temperature effects on the nonspecific immune system are less well characterised, but there is evidence that low temperatures are also suppressive. Knowledge of immune system function becomes essential for disease prevention strategies such as the development of vaccines, selection for increased disease resistance and identification of genes suitable for trangenesis.

Item Type:	Refereed Article
Research Division:	Agricultural, Veterinary and Food Sciences
Research Group:	Veterinary sciences
Research Field:	Veterinary immunology
Objective Division:	Animal Production and Animal Primary Products
Objective Group:	Fisheries - aquaculture
Objective Field:	Fisheries - aquaculture not elsewhere classified
UTAS Author:	Watts, M (Dr Marianne Watts)
UTAS Author:	Munday, BL (Dr Barry Munday)
UTAS Author:	Burke, CM (Dr Chris Burke)
ID Code:	21443
Year Published:	2001
Web of Science® Times Cited:	121
Deposited By:	TAFI - Aquaculture
Deposited On:	2001-08-01
Last Modified:	2002-06-12
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