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Characterization and regulation of tachykinin receptors in the nucleus tractus solitarius

Citation

Mazzone, SB and Geraghty, DP, Characterization and regulation of tachykinin receptors in the nucleus tractus solitarius, Clinical and Experimental Pharmacology and Physiology, 27, (11) pp. 939-942. ISSN 0305-1870 (2000) [Refereed Article]

DOI: doi:10.1046/j.1440-1681.2000.03365.x

Abstract

1. The characteristics, localization and regulation of tachykinin receptors in the rat nucleus tractus solitarius (NTS) involved in respiratory control were investigated using a combination of in vivo microinjection and in vitro autoradiographic techniques. 2. Microinjection of receptor-selective tachykinin agonists and antagonists into the NTS of urethane-anaesthetized rats suggests that stimulation of NK1 and NK3 receptors increases tidal volume, whereas NK2 and NK3 receptor activation produces a bradypnoea. 3. Depletion of NK1 receptors in the NTS due to either ageing or acute hypoxia correlates with a markedly reduced respiratory response to substance P. In contrast, chemical ablation of sensory neurons by neonatal capsaicin administration dramatically increases the respiratory response to a variety of NK1, NK2 and NK3 agonists. 4. These studies suggest that all three tachykinin receptors are present in the rat NTS and that these receptors are subject to both acute and chronic regulation.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Basic Pharmacology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Mazzone, SB (Mr Stuart Brett Mazzone)
Author:Geraghty, DP (Professor Dominic Geraghty)
ID Code:21064
Year Published:2000
Web of Science® Times Cited:15
Deposited By:Health Sciences A
Deposited On:2000-08-01
Last Modified:2011-08-04
Downloads:0

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