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Neuronal Response to Physical Injury and its Relationship to the Pathology of Alzheimer's Disease

journal contribution
posted on 2023-05-16, 12:36 authored by Carolyn KingCarolyn King, Adlard, PA, Tracey DicksonTracey Dickson, James VickersJames Vickers
1. Central nerve cells undergo a stereotyped regenerative response following physical injury. 2. This reaction involves adaptive changes within the axon and cell body of origin, directed at sprouting and synaptogenesis. 3. Intimately associated with the regenerative response are specific alterations to cytoskeletal proteins, including the neurofilament (NF) triplet. 4. The morphological and neurochemical alterations to NF within axons following injury are reminiscent of plaque-associated dystrophic neurites (DN) in early Alzheimer's disease (AD). 5. Associated changes in perikaryal NF resemble Alzheimer neurofibrillary tangle pathology, while growth-associated sprouting markers are localized to the abnormal neurites of AD. 6. The present review postulates that β-amyloid plaques in AD cause physical damage to local nerve cell processes and it is the chronic stimulation of the stereotyped response to injury that results in the end- stage pathology and neurodegeneration associated with AD.

History

Publication title

Clinical and Experimental Pharmacology and Physiology

Volume

27

Issue

7

Pagination

548-552

ISSN

0305-1870

Department/School

Tasmanian School of Medicine

Publisher

Blackwell Sciences

Place of publication

Australia

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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