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Neuronal Response to Physical Injury and its Relationship to the Pathology of Alzheimer's Disease

Citation

King, CE and Adlard, PA and Dickson, TC and Vickers, JC, Neuronal Response to Physical Injury and its Relationship to the Pathology of Alzheimer's Disease, Clinical and Experimental Pharmacology and Physiology, 27, (7) pp. 548-552. ISSN 0305-1870 (2000) [Refereed Article]

DOI: doi:10.1046/j.1440-1681.2000.03292.x

Abstract

1. Central nerve cells undergo a stereotyped regenerative response following physical injury. 2. This reaction involves adaptive changes within the axon and cell body of origin, directed at sprouting and synaptogenesis. 3. Intimately associated with the regenerative response are specific alterations to cytoskeletal proteins, including the neurofilament (NF) triplet. 4. The morphological and neurochemical alterations to NF within axons following injury are reminiscent of plaque-associated dystrophic neurites (DN) in early Alzheimer's disease (AD). 5. Associated changes in perikaryal NF resemble Alzheimer neurofibrillary tangle pathology, while growth-associated sprouting markers are localized to the abnormal neurites of AD. 6. The present review postulates that β-amyloid plaques in AD cause physical damage to local nerve cell processes and it is the chronic stimulation of the stereotyped response to injury that results in the end- stage pathology and neurodegeneration associated with AD.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:King, CE (Dr Carolyn King)
Author:Adlard, PA (Dr Paul Anthony Adlard)
Author:Dickson, TC (Professor Tracey Dickson)
Author:Vickers, JC (Professor James Vickers)
ID Code:20359
Year Published:2000
Web of Science® Times Cited:15
Deposited By:Pathology
Deposited On:2000-08-01
Last Modified:2011-07-06
Downloads:0

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