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Acute CNS axonal injury models a subtype of dystrophic neurite in Alzheimer's Disease

journal contribution
posted on 2023-05-16, 12:35 authored by Carolyn KingCarolyn King, Tracey DicksonTracey Dickson, Jacobs, I, Graeme McCormackGraeme McCormack, Riederer, BM, James VickersJames Vickers
The morphological and neurochemical sequelae of physical injury to cortical axons were investigated for their similarity to a subtype of dystrophic neurite in Alzheimer's disease (AD). A 25 gauge needle was inserted into the cortex of anaesthetised rats for 10 min. At 1 day post-injury, neurofilament-immunoreactive bulb- and ring-like abnormal neurites were present along the needle tract edge. Double labelling immunohistochemistry demonstrated colocalisation of neurofilament subunits with different phosphorylation states within the same reactive axonal structures. Ultrastructurally, bulb-like axons contained neurofilaments and abnormal structures such as dense-core vesicles and multilamellar bodies. Ring-like structures corresponded to collapsed myelinated axons or axon terminals, with bands of neurofilaments surrounding central mitochondria and/or other organelles. All of these reactive axons lacked microtubules. The morphological, neurochemical and ultrastructural features of axons responding to physical trauma resemble the cellular alterations within a subset of dystrophic neurites in AD, particularly in the early stages of the condition. ©MSJ.

History

Publication title

Alzheimer's Reports

Pagination

31-40

ISSN

1461-6130

Department/School

Tasmanian School of Medicine

Publisher

Medical Science Journals

Place of publication

Wales, UK

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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