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Acute CNS axonal injury models a subtype of dystrophic neurite in Alzheimer's Disease


King, CE and Dickson, TC and Jacobs, I and McCormack, GH and Riederer, BM and Vickers, JC, Acute CNS axonal injury models a subtype of dystrophic neurite in Alzheimer's Disease, Alzheimer's Reports, 3, (1) pp. 31-40. ISSN 1461-6130 (2000) [Refereed Article]


The morphological and neurochemical sequelae of physical injury to cortical axons were investigated for their similarity to a subtype of dystrophic neurite in Alzheimer's disease (AD). A 25 gauge needle was inserted into the cortex of anaesthetised rats for 10 min. At 1 day post-injury, neurofilament-immunoreactive bulb- and ring-like abnormal neurites were present along the needle tract edge. Double labelling immunohistochemistry demonstrated colocalisation of neurofilament subunits with different phosphorylation states within the same reactive axonal structures. Ultrastructurally, bulb-like axons contained neurofilaments and abnormal structures such as dense-core vesicles and multilamellar bodies. Ring-like structures corresponded to collapsed myelinated axons or axon terminals, with bands of neurofilaments surrounding central mitochondria and/or other organelles. All of these reactive axons lacked microtubules. The morphological, neurochemical and ultrastructural features of axons responding to physical trauma resemble the cellular alterations within a subset of dystrophic neurites in AD, particularly in the early stages of the condition. ©MSJ.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:King, CE (Dr Carolyn King)
UTAS Author:Dickson, TC (Professor Tracey Dickson)
UTAS Author:Jacobs, I (Mrs Irene Jacobs)
UTAS Author:McCormack, GH (Mr Graeme McCormack)
UTAS Author:Vickers, JC (Professor James Vickers)
ID Code:20357
Year Published:2000
Web of Science® Times Cited:7
Deposited By:Pathology
Deposited On:2000-08-01
Last Modified:2001-05-04

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