eCite Digital Repository

Changes in the management of acute myocardial infarction in Southern Tasmania


McNamara, KS and Peterson, GM and Friesen, WT, Changes in the management of acute myocardial infarction in Southern Tasmania, Journal of Clinical Pharmacy and Therapeutics, 25, (2) pp. 111-118. ISSN 0269-4727 (2000) [Refereed Article]

Not available

Copyright Statement

The definitive published version is available online at:

Official URL:

DOI: doi:10.1046/j.1365-2710.2000.00269.x


Background: In recent years, the management of acute myocardial infarction (AMI) has been the subject of many clinical trials. These studies have clearly established the value of using pharmacological agents, including aspirin, -blockers, thrombolytics and angiotensin converting enzyme (ACE) inhibitors. There have been suggestions, however, that practice has been slow to change in light of the findings of these trials. Aim: To review cases of AMI at the major teaching hospital in Tasmania, Australia, to determine whether the recommendations from the results of the trials had been translated into local clinical practice, and to examine temporal changes in drug usage and clinical outcomes. Methods: A retrospective review of the medical records of patients admitted to the hospital with an AMI during 1996 and for the first four months of 1998 was performed. An extensive range of demographic and clinical variables was recorded, and differences between the 1996 and 1998 patients and between recipients and non-recipients of the different pharmacological agents were statistically evaluated. Results: The patients had a mean age of 659 123 years in 1996 (n = 205) and 668 123 years in 1998 (n = 71), with males accounting for 644% of cases in 1996 and 648% of cases in 1998. There were no significant demographic or medical history differences between the two groups. The median time of presentation after the onset of chest pain was 35 h in 1996 and 4 h in 1998. The rates of use of major therapeutic interventions post-AMI for 1996 and 1998, respectively, were: aspirin (891%, 903%), streptokinase (185%, 99%), r-tPA (141%, 211%), intravenous -blockers (112%, 70%), oral -blockers (672%, 493%; P < 001), ACE inhibitors (444%, 592%; P < 005), intravenous nitrate (941%, 916%), oral nitrate (229%, 268%), calcium channel antagonists (195%, 352%; P < 005), cholesterol lowering agents (263%, 409%; P < 005), antiarrhythmics (215%, 254%) and warfarin (83%, 99%). Patients who received therapy with each of aspirin, r-tPA, intravenous -blockers, oral -blockers, intravenous nitrate and cholesterol lowering agents were significantly younger than the non-recipients (all P < 001), while patients treated with ACE inhibitors and antiarrhythmics were significantly older than the non-recipients (both P < 0001). Non-recipients of thrombolytics presented to hospital significantly later, on average, than recipients. The hospital mortality rate was 151% in 1996 and 127% in 1998, and adverse drug reactions occurred in 215% of patients in 1996 and 155% in 1998. Conclusions: Although there have been substantial increases in the use of ACE inhibitors and cholesterol lowering agents post-AMI in recent years, reductions in the use of thrombolytics and -blockers and their possible underuse in the elderly are of concern and warrant intervention.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:McNamara, KS (Ms K. McNamara)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Friesen, WT (Dr William Friesen)
ID Code:19949
Year Published:2000
Web of Science® Times Cited:3
Deposited By:Pharmacy
Deposited On:2000-08-01
Last Modified:2011-08-04

Repository Staff Only: item control page