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Neurotrophic factors in the primary olfactory pathway
Citation
Mackay-Sim, A and Chuah, MI, Neurotrophic factors in the primary olfactory pathway, Progress in Neurobiology, 62, (5) pp. 527-559. ISSN 0301-0082 (2000) [Refereed Article]
DOI: doi:10.1016/S0301-0082(00)00009-5
Abstract
The number of identified growth factors continues to increase rapidly with many being implicated in the development of the nervous system, although for most of them the autocrine and paracrine pathways of cellular regulation still remain to be elucidated. The primary olfactory pathway, consisting of the olfactory epithelium and olfactory bulb, is presented here as a very useful model for the analysis of growth factor function. Review of the available literature suggests that a large proportion of neuroactive growth factors and their receptors are present in the olfactory epithelium or olfactory bulb. Furthermore, the primary olfactory pathway is one of the most plastic in the nervous system with neurogenesis continuing to contribute new sensory neurones in the olfactory epithelium and new interneurones in the olfactory bulb throughout adult life. The rich diversity of growth factors and their receptors in the olfactory system indicates that it will be useful in elucidating how these molecules regulate the formation of the nervous system. The olfactory epithelium in particular is proving useful as a model for the actions of growth factors in directing the neuronal lineage from stem cell to mature neurone. (C) 2000 Elsevier Science Ltd.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Sensory systems |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Chuah, MI (Associate Professor Inn Chuah) |
ID Code: | 19719 |
Year Published: | 2000 |
Web of Science® Times Cited: | 113 |
Deposited By: | Anatomy and Physiology |
Deposited On: | 2000-08-01 |
Last Modified: | 2011-08-04 |
Downloads: | 0 |
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