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Rattus norvegicus: not a model for Aeromonas - associated gastroenteritis in man


Kelleher, AM and Kirov, SM, Rattus norvegicus: not a model for Aeromonas - associated gastroenteritis in man, FEMS - Immunology and Medical Microbiology, 28, (4) pp. 313-318. ISSN 0928-8244 (2000) [Refereed Article]

DOI: doi:10.1016/S0928-8244(00)00172-3


The lack of a suitable animal model of Aeromonas-associated diarrhoea has hampered investigations into Aeromonas pathogenic mechanisms. Hence, a published report that clindamycin-pretreated rats developed signs and symptoms of enteritis following intragastric inoculation of an Aeromonas strain required further investigation. Although we could demonstrate long-term colonisation (>12 days) and histological damage in this animal model with Pseudomonas aeruginosa isolated from patients with chronic diarrhoea, this was not seen with Aeromonas spp. Six Aeromonas strains, selected for their potential virulence and colonising abilities and including the strain from the original report, were either not recovered from stools or were recovered for no longer than 2 days post inoculation. Intestinal histology remained normal. Destruction of bacteria in vivo appeared to be due to immune mechanisms as inoculum strains were not 'suicidal' or unduly sensitive to low pH or clindamycin. This study was, therefore, unable to validate the clindamycin-treated rat model as a useful one for investigating the enteropathogenicity of Aeromonas species. Possible reasons for the discrepancy between our study and the original report are discussed. Copyright (C) 2000 Federation of European Microbiological Societies.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Medical microbiology
Research Field:Medical bacteriology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Kelleher, AM (Mr Adrian Kelleher)
UTAS Author:Kirov, SM (Associate Professor Sylvia Kirov)
ID Code:19610
Year Published:2000
Web of Science® Times Cited:4
Deposited By:Pathology
Deposited On:2000-08-01
Last Modified:2001-07-27

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