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Malignant melanoma in patients with multiple endocrine neoplasia type 1 and involvement of the meni gene in sporadic melanoma

Citation

Nord, B and Platz, A and Smoczynski, K and Kytola, S and Robertson, G and Calender, A and Murat, A and Weintraub, D and Burgess, J and Edwards, M and Skogseid, B and Owen, D and Lassam, N and Hogg, D and Larsson, C and Teh, BT, Malignant melanoma in patients with multiple endocrine neoplasia type 1 and involvement of the meni gene in sporadic melanoma, International Journal of Cancer, 87 pp. 463-467. ISSN 0020-7136 (2000) [Refereed Article]

DOI: doi:10.1002/1097-0215(20000815)87:4<463::AID-IJC1>3.0.CO;2-8

Abstract

Multiple endocrine neoplasia type 1 (MEN 1) is a familial cancer syndrome associated primarily with endocrine tumors of the parathyroids, enteropancreas and anterior pituitary. However, tumors of mesenchymal origin such as angiofibroma and collagenoma of the skin have also been associated with the syndrome. This highlights the possibility of an association between MEN 1 and some other types of tumors. Here we report 7 cases of primary malignant melanoma occurring in 7 MEN 1 families, all patients exhibiting classic features of MEN 1. Based on these findings and the previous implication of multiple melanoma tumor suppressor(s) in 11q, including the MEN 1 region, we have investigated the involvement of the MEN 1 gene in melanoma tumorigenesis. Mutation analysis was performed on a panel of 39 sporadic metastatic melanomas, 13 melanoma cell lines and 20 melanoma families without CDKN2A or CDK4 germline mutations. In addition, 19 sporadic metastatic tumors were screened for loss of heterozygosity (LOH) in 11q13. LOH was detected in 6 tumors (32%), and in 4 of the tumors the pattern of LOH suggested that the deletion included the MEN1 gene locus. A novel somatic nonsense mutation in exon 7 (Q349X) was identified in 1 sporadic tumor which also showed loss of the wild-type allele. We conclude that the MEN1 gene plays a role in the tumorigenesis of a small subgroup of melanoma. (C) 2000 Wiley-Liss, Inc.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Burgess, J (Mr Jeff Burgess)
ID Code:19551
Year Published:2000
Web of Science® Times Cited:28
Deposited By:Medicine (Discipline)
Deposited On:2000-08-01
Last Modified:2001-05-03
Downloads:0

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