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The immunomodulatory effects of levamisole on the nonspecific immune system of Atlantic salmon, Salmo salar L
journal contribution
posted on 2023-05-16, 12:08 authored by Findlay, VL, Munday, BLSea water-adapted Atlantic salmon, Salmo salar L., were given a 2-h bath in a 2.5 mg L -1 levamisole (as levamisole hydrochloride) solution in fresh-water. Following bathing, the fish were held in full salinity sea water for 2 weeks before being subjected to a number of immunological assays. Heightened activity of the nonspecific defence system was demonstrated by increases in phagocytic index, phagocytic capacity and phagocytic activity, increased levels of the reactive oxygen intermediate, superoxide anion, and an increased lytic activity of both the mucus and the serum. These results indicate that levamisole is effective in augmenting parts of the nonspecific defence system of Atlantic salmon. This is the first record of the use and efficacy of levamisole as an immunomodulator in Atlantic salmon.
History
Publication title
Journal of Fish DiseasesVolume
23Issue
6Pagination
369-378ISSN
0140-7775Department/School
Institute for Marine and Antarctic StudiesPublisher
Blackwell Science LtdPlace of publication
Oxford, EnglandRepository Status
- Restricted